Role of nitrosative stress and poly(ADP-ribose) polymerase activation in myocardial reperfusion injury

Gábor Szabó, Susanne Bährle

Research output: Review article

30 Citations (Scopus)

Abstract

Ischemia and reperfusion injury leads to a complex pathophysiological process, which in turn results in the generation of free radicals. Peroxynitrite, a highly reactive species causes DNA single strand breaks, which activates the nuclear enzyme, poly (ADP-ribose) polymerase (PARP). The activation of PARP leads to an energy consuming inefficient repair cycle with subsequent depletion of NAD+ and ATP pools and necrotic cell death. The present review overviews the pathophysiological role of the peroxynitrite-PARP pathway in cardiac ischemia/reperfusion injury with special reference to the therapeutic potential of PARP inhibitors in the treatment of this disease.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalCurrent Vascular Pharmacology
Volume3
Issue number3
DOIs
Publication statusPublished - júl. 1 2005

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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