Abstract
The virulence of deletion mutants of pseudorabies virus defective in the expression of glycoprotein gI, gp63, or both was tested in 1-day-old chickens and young pigs. In the absence of expression of gI, the virulence of a fully virulent laboratory strain, PrV(Ka), for 1-day-old chickens was reduced approximately fourfold. Inactivation of glycoprotein gp63 appeared also to affect the virulence of PrV(Ka) only slightly, as did inactivation of both gI and gp63. The level of reduction in virulence, however, was considerably more marked in Bartha 43/25aB4, a less virulent virus strain. Inactivation of the expression of gI in Bartha 43/25aB4 reduced virulence for chickens at least 100-fold. The results obtained when the virulence of the mutants for pigs was determined were compatible with those obtained for chickens. These results indicate that gI plays a role in virulence, but that it does so in conjunction with at least one other viral function (a function that is defective in Bartha 43/25aB4).
| Original language | English |
|---|---|
| Pages (from-to) | 4030-4032 |
| Number of pages | 3 |
| Journal | Journal of Virology |
| Volume | 61 |
| Issue number | 12 |
| Publication status | Published - 1987 |
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ASJC Scopus subject areas
- Immunology
Cite this
Role of a structural glycoprotein of pseudorabies in virus virulence. / Mettenleiter, T. C.; Zsak, L.; Kaplan, A. S.; Ben-Porat, T.; Lomniczi, B.
In: Journal of Virology, Vol. 61, No. 12, 1987, p. 4030-4032.Research output: Article
}
TY - JOUR
T1 - Role of a structural glycoprotein of pseudorabies in virus virulence
AU - Mettenleiter, T. C.
AU - Zsak, L.
AU - Kaplan, A. S.
AU - Ben-Porat, T.
AU - Lomniczi, B.
PY - 1987
Y1 - 1987
N2 - The virulence of deletion mutants of pseudorabies virus defective in the expression of glycoprotein gI, gp63, or both was tested in 1-day-old chickens and young pigs. In the absence of expression of gI, the virulence of a fully virulent laboratory strain, PrV(Ka), for 1-day-old chickens was reduced approximately fourfold. Inactivation of glycoprotein gp63 appeared also to affect the virulence of PrV(Ka) only slightly, as did inactivation of both gI and gp63. The level of reduction in virulence, however, was considerably more marked in Bartha 43/25aB4, a less virulent virus strain. Inactivation of the expression of gI in Bartha 43/25aB4 reduced virulence for chickens at least 100-fold. The results obtained when the virulence of the mutants for pigs was determined were compatible with those obtained for chickens. These results indicate that gI plays a role in virulence, but that it does so in conjunction with at least one other viral function (a function that is defective in Bartha 43/25aB4).
AB - The virulence of deletion mutants of pseudorabies virus defective in the expression of glycoprotein gI, gp63, or both was tested in 1-day-old chickens and young pigs. In the absence of expression of gI, the virulence of a fully virulent laboratory strain, PrV(Ka), for 1-day-old chickens was reduced approximately fourfold. Inactivation of glycoprotein gp63 appeared also to affect the virulence of PrV(Ka) only slightly, as did inactivation of both gI and gp63. The level of reduction in virulence, however, was considerably more marked in Bartha 43/25aB4, a less virulent virus strain. Inactivation of the expression of gI in Bartha 43/25aB4 reduced virulence for chickens at least 100-fold. The results obtained when the virulence of the mutants for pigs was determined were compatible with those obtained for chickens. These results indicate that gI plays a role in virulence, but that it does so in conjunction with at least one other viral function (a function that is defective in Bartha 43/25aB4).
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UR - http://www.scopus.com/inward/citedby.url?scp=0023521609&partnerID=8YFLogxK
M3 - Article
C2 - 2824832
AN - SCOPUS:0023521609
VL - 61
SP - 4030
EP - 4032
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 12
ER -