Risk of colorectal cancer in Crohn's disease patients with colonic involvement and stenosing disease in a population-based cohort from Hungary

Barbara D. Lovasz, L. Lakatos, Petra A. Golovics, Gyula David, T. Pandúr, Z. Erdélyi, Mihaly Balogh, Istvan Szita, Csaba Molnar, Erzsebet Komaromi, Zsuzsanna Vegh, Michael D. Mandel, Lajos S. Kiss, P. Lakatos

Research output: Article

19 Citations (Scopus)

Abstract

Background & Aims: Since data is limited regarding the risk of colorectal cancer (CRC) in Crohn's disease (CD) patients who present with stenosing disease in the colon, this study was undertaken to assess CRC risk in such patients, using a population-based, Veszprem province database, which includes incidental patients diagnosed between January 1, 1977 and December 31, 2011. Methods: Data from 640 incidental CD patients were analyzed (M/F ratio: 321/319, age-at-diagnosis: 28 years (IQR: 22-38)). Both hospital and outpatient records were collected and comprehensively reviewed. Results: CRC was diagnosed in six CD patients during a follow-up of 7759 person-years. Sixty-two patients presented with colonic/ileocolonic disease and a stenotic lesion in the colon with a follow-up of 702 personyears (median:10.5, IQR:5-16years). Colorectal cancer developed in 6.5% (equaling 0.57/100person-years), the SIR (6.53, 95%CI:2.45-17.4) was increased with four patients observed versus 0.61 expected. In a Kaplan- Meier analysis, the probability of developing CRC was 5.5% and 7.5% after 5- and 10 years, respectively, versus 0.4% in patients with other phenotypes (HR:18.8, p

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalJournal of gastrointestinal and liver diseases : JGLD
Volume22
Issue number3
Publication statusPublished - szept. 2013

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Hungary
Crohn Disease
Colorectal Neoplasms
Population
Colon
Colonic Diseases
Hospital Records
Kaplan-Meier Estimate
Outpatients
Databases
Phenotype

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Risk of colorectal cancer in Crohn's disease patients with colonic involvement and stenosing disease in a population-based cohort from Hungary. / Lovasz, Barbara D.; Lakatos, L.; Golovics, Petra A.; David, Gyula; Pandúr, T.; Erdélyi, Z.; Balogh, Mihaly; Szita, Istvan; Molnar, Csaba; Komaromi, Erzsebet; Vegh, Zsuzsanna; Mandel, Michael D.; Kiss, Lajos S.; Lakatos, P.

In: Journal of gastrointestinal and liver diseases : JGLD, Vol. 22, No. 3, 09.2013, p. 265-268.

Research output: Article

Lovasz, Barbara D. ; Lakatos, L. ; Golovics, Petra A. ; David, Gyula ; Pandúr, T. ; Erdélyi, Z. ; Balogh, Mihaly ; Szita, Istvan ; Molnar, Csaba ; Komaromi, Erzsebet ; Vegh, Zsuzsanna ; Mandel, Michael D. ; Kiss, Lajos S. ; Lakatos, P. / Risk of colorectal cancer in Crohn's disease patients with colonic involvement and stenosing disease in a population-based cohort from Hungary. In: Journal of gastrointestinal and liver diseases : JGLD. 2013 ; Vol. 22, No. 3. pp. 265-268.
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AU - Lakatos, L.

AU - Golovics, Petra A.

AU - David, Gyula

AU - Pandúr, T.

AU - Erdélyi, Z.

AU - Balogh, Mihaly

AU - Szita, Istvan

AU - Molnar, Csaba

AU - Komaromi, Erzsebet

AU - Vegh, Zsuzsanna

AU - Mandel, Michael D.

AU - Kiss, Lajos S.

AU - Lakatos, P.

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