Ring-chain tautomerism of 2-aryl-substituted-hexahydropyrimidines and tetrahydroquinazolines

Anikó Göblyös, László Lázár, Ferenc Fülöp

Research output: Article

41 Citations (Scopus)

Abstract

2-Aryl-substituted-1-isopropyl- and 1-phenylhexahydropyrimidines and 3-isopropyl- and 3-phenyl-1,2,3,4-tetrahydroquinazolines proved to be ring-chain tautomeric mixtures in CDCl3 at 300K, whereas only ring-closed tautomers could be detected for the 1- or 3-methyl-substituted analogues. The ratios of the ring-chain tautomeric forms at equilibrium could be described by the equation log KX = ρσ+ + log KX=H.

Original languageEnglish
Pages (from-to)1011-1016
Number of pages6
JournalTetrahedron
Volume58
Issue number5
DOIs
Publication statusPublished - jan. 28 2002

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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