Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation

M. Mohty, F. Malard, M. Abecassis, E. Aerts, A. S. Alaskar, M. Aljurf, M. Arat, P. Bader, F. Baron, A. Bazarbachi, D. Blaise, F. Ciceri, S. Corbacioglu, J. H. Dalle, F. Dignan, T. Fukuda, A. Huynh, T. Masszi, M. Michallet, A. NaglerM. NiChonghaile, S. Okamoto, A. Pagliuca, C. Peters, F. B. Petersen, P. G. Richardson, T. Ruutu, B. N. Savani, E. Wallhult, I. Yakoub-Agha, R. F. Duarte, E. Carreras

Research output: Article

85 Citations (Scopus)

Abstract

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.Bone Marrow Transplantation advance online publication, 16 May 2016; doi:10.1038/bmt.2016.130.

Original languageEnglish
JournalBone Marrow Transplantation
DOIs
Publication statusAccepted/In press - máj. 16 2016

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Hepatic Veno-Occlusive Disease
Transplantation
Bone Marrow
Cell Transplantation
Bone Marrow Transplantation
Publications
Sensitivity and Specificity
Mortality
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients : a new classification from the European Society for Blood and Marrow Transplantation. / Mohty, M.; Malard, F.; Abecassis, M.; Aerts, E.; Alaskar, A. S.; Aljurf, M.; Arat, M.; Bader, P.; Baron, F.; Bazarbachi, A.; Blaise, D.; Ciceri, F.; Corbacioglu, S.; Dalle, J. H.; Dignan, F.; Fukuda, T.; Huynh, A.; Masszi, T.; Michallet, M.; Nagler, A.; NiChonghaile, M.; Okamoto, S.; Pagliuca, A.; Peters, C.; Petersen, F. B.; Richardson, P. G.; Ruutu, T.; Savani, B. N.; Wallhult, E.; Yakoub-Agha, I.; Duarte, R. F.; Carreras, E.

In: Bone Marrow Transplantation, 16.05.2016.

Research output: Article

Mohty, M, Malard, F, Abecassis, M, Aerts, E, Alaskar, AS, Aljurf, M, Arat, M, Bader, P, Baron, F, Bazarbachi, A, Blaise, D, Ciceri, F, Corbacioglu, S, Dalle, JH, Dignan, F, Fukuda, T, Huynh, A, Masszi, T, Michallet, M, Nagler, A, NiChonghaile, M, Okamoto, S, Pagliuca, A, Peters, C, Petersen, FB, Richardson, PG, Ruutu, T, Savani, BN, Wallhult, E, Yakoub-Agha, I, Duarte, RF & Carreras, E 2016, 'Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation', Bone Marrow Transplantation. https://doi.org/10.1038/bmt.2016.130
Mohty, M. ; Malard, F. ; Abecassis, M. ; Aerts, E. ; Alaskar, A. S. ; Aljurf, M. ; Arat, M. ; Bader, P. ; Baron, F. ; Bazarbachi, A. ; Blaise, D. ; Ciceri, F. ; Corbacioglu, S. ; Dalle, J. H. ; Dignan, F. ; Fukuda, T. ; Huynh, A. ; Masszi, T. ; Michallet, M. ; Nagler, A. ; NiChonghaile, M. ; Okamoto, S. ; Pagliuca, A. ; Peters, C. ; Petersen, F. B. ; Richardson, P. G. ; Ruutu, T. ; Savani, B. N. ; Wallhult, E. ; Yakoub-Agha, I. ; Duarte, R. F. ; Carreras, E. / Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients : a new classification from the European Society for Blood and Marrow Transplantation. In: Bone Marrow Transplantation. 2016.
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abstract = "Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80{\%}). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.Bone Marrow Transplantation advance online publication, 16 May 2016; doi:10.1038/bmt.2016.130.",
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AU - Alaskar, A. S.

AU - Aljurf, M.

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AU - Richardson, P. G.

AU - Ruutu, T.

AU - Savani, B. N.

AU - Wallhult, E.

AU - Yakoub-Agha, I.

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