Retrospective detection of a subclinical hepatitis A virus (HAV) epidemic affecting juvenile cohorts of the Hungarian population

Ödön Pohl, Judit Brojnás, Erzsébet Rusvai, Katalin Ördög, Ilona Siska, Gábor Faludi, Beatrix Kapusinszky, Ágnes Csohán, Katalin Lendvai, Anna Lengyel, Ilona Mezey, György Berencsi

Research output: Article

7 Citations (Scopus)

Abstract

Sero-epidemiological surveys of serum samples taken in 1982, 1987, 1994 and 1999 have been performed with hepatitis A virus-specific (HAV-specific) serological tests. Results obtained during these surveys show that the proportion of seropositive blood donors decreased from 69% to 18% within 17 years. The authors have recognised a (mainly subclinical) epidemic, affecting about 115 000 teenagers in 1992-1994 in Hungary, is a threatening phenomenon. It was calculated that only about 3600 clinical diseases were associated with the epidemic, recognised retrospectively from the findings of the four sero-epidemiological surveys. Epidemiological data indicated that the excess clinical diseases caused by HAV concentrated in the southern counties of Hungary, which have been affected by the social and military activities between 1992 and 1994. Due to the decrease of subjects seropositive for HAV, sera from preselected or actively immunised donors will be required in the future and vaccination against HAV with killed virus is likely to be recommended for risk groups. Furthermore, health authorities might promote active immunisation of young children against HAV infection; for that, promotion of manufacturing combination vaccines of HAV/HBV/DPT or, for certain countries, HAV/DPT would be desirable.

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalFEMS Immunology and Medical Microbiology
Volume38
Issue number1
DOIs
Publication statusPublished - aug. 18 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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    Pohl, Ö., Brojnás, J., Rusvai, E., Ördög, K., Siska, I., Faludi, G., Kapusinszky, B., Csohán, Á., Lendvai, K., Lengyel, A., Mezey, I., & Berencsi, G. (2003). Retrospective detection of a subclinical hepatitis A virus (HAV) epidemic affecting juvenile cohorts of the Hungarian population. FEMS Immunology and Medical Microbiology, 38(1), 85-91. https://doi.org/10.1016/S0928-8244(03)00143-3