The resolution methods previously developed for the enantioseparation of heterocyclic phosphine oxides were extended to dialkyl-aryl-, diaryl-alkyl- and triarylphosphine oxides. The resolution of the phosphine oxides were elaborated with TADDOL-derivatives or with the acidic Ca2+-salts of the (R,R)-O,O’-dibenzoyl- and (R,R)-O,O’-di-p-toluoyl-tartaric acid. The main parameters influencing the efficiency of the resolution procedures were also optimized. Moreover, a correlation was found between the efficiency of the resolution and molecular structure. In a few instances, the purification and the racemization possibilities of the enantiomeric mixtures were also investigated.
|Journal||Phosphorus, Sulfur and Silicon and the Related Elements|
|Publication status||Published - jan. 1 2019|
ASJC Scopus subject areas
- Organic Chemistry
- Inorganic Chemistry