Renal electrolyte and water handling in normal pregnancy: possible role of endothelin-1

P. Tamás, S. Worgall, E. Sulyok, W. Rascher

Research output: Article

8 Citations (Scopus)

Abstract

The study was carried out to determine the urinary excretion of endothelin-1 (ET-1) in normal pregnancy and to define its possible role in mediating the renal response to aldosterone and arginine vasopressin (AVP). Measurements were performed in 12 healthy pregnant women serially in the 20th, 24th, 28th, 32nd and 36th weeks of pregnancy. Urinary ET-1, plasma and urinary aldosterone and AVP levels (RIA methods) as well as plasma and urine sodium, potassium, creatinine and osmolality were measured; creatinine clearance (Ccr), osmolar clearance (Cosm) and free water clearance (CH2O) calculated. Fractional sodium excretion (FENa), urine sodium/potassium ratio ( Na K) and transtubular potassium concentration gradient (TTKG) were also determined. It was demonstrated that urinary ET-1 excretion was higher in pregnant than in non-pregnant women and it increased further as the pregnancy progressed from 34.8 ± 4.0 pmol/day in week 20 to 44.1 ± 3.2 pmol/day in week 36 (P <0.01). Daily ET-1 excretion significantly correlated with AVP (r = 0.39, P <0.005) and aldosterone excretion (r = 0.62, P <0.0001). Furthermore, there was a significant positive relationship between ET-1 excretion and urine flow rate (r = 0.67, P <0.0001), CCR (r = 0.40, P <0.0025), Cosm (r = 0.58, P <0.001), sodium (r = 0.56, P <0.001) and potassium excretion (r = 0.42, P <0.001). However, such a relationship could not be established between ET-1 excretion and FENa, TTKG and Na K. It is concluded that the activated reninangiotensin-aldosterone system, the augmented AVP secretion and the reduced renal medullary tonicity might contribute to the increased renal ET-1 production in pregnancy, which might modulate the renal response to aldosterone and AVP.

Original languageEnglish
Pages (from-to)89-95
Number of pages7
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume55
Issue number2
DOIs
Publication statusPublished - jún. 15 1994

Fingerprint

endothelins
Endothelin-1
Electrolytes
electrolytes
arginine vasopressin
Arginine Vasopressin
excretion
aldosterone
kidneys
Aldosterone
pregnancy
Kidney
Pregnancy
Water
Potassium
Sodium
water
potassium
sodium
Urine

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Agricultural and Biological Sciences(all)

Cite this

@article{1534ebf9ac1b441591f859c96a506b72,
title = "Renal electrolyte and water handling in normal pregnancy: possible role of endothelin-1",
abstract = "The study was carried out to determine the urinary excretion of endothelin-1 (ET-1) in normal pregnancy and to define its possible role in mediating the renal response to aldosterone and arginine vasopressin (AVP). Measurements were performed in 12 healthy pregnant women serially in the 20th, 24th, 28th, 32nd and 36th weeks of pregnancy. Urinary ET-1, plasma and urinary aldosterone and AVP levels (RIA methods) as well as plasma and urine sodium, potassium, creatinine and osmolality were measured; creatinine clearance (Ccr), osmolar clearance (Cosm) and free water clearance (CH2O) calculated. Fractional sodium excretion (FENa), urine sodium/potassium ratio ( Na K) and transtubular potassium concentration gradient (TTKG) were also determined. It was demonstrated that urinary ET-1 excretion was higher in pregnant than in non-pregnant women and it increased further as the pregnancy progressed from 34.8 ± 4.0 pmol/day in week 20 to 44.1 ± 3.2 pmol/day in week 36 (P <0.01). Daily ET-1 excretion significantly correlated with AVP (r = 0.39, P <0.005) and aldosterone excretion (r = 0.62, P <0.0001). Furthermore, there was a significant positive relationship between ET-1 excretion and urine flow rate (r = 0.67, P <0.0001), CCR (r = 0.40, P <0.0025), Cosm (r = 0.58, P <0.001), sodium (r = 0.56, P <0.001) and potassium excretion (r = 0.42, P <0.001). However, such a relationship could not be established between ET-1 excretion and FENa, TTKG and Na K. It is concluded that the activated reninangiotensin-aldosterone system, the augmented AVP secretion and the reduced renal medullary tonicity might contribute to the increased renal ET-1 production in pregnancy, which might modulate the renal response to aldosterone and AVP.",
keywords = "Pregnancy, Renal functions, Urinary endothelin-1",
author = "P. Tam{\'a}s and S. Worgall and E. Sulyok and W. Rascher",
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T1 - Renal electrolyte and water handling in normal pregnancy

T2 - possible role of endothelin-1

AU - Tamás, P.

AU - Worgall, S.

AU - Sulyok, E.

AU - Rascher, W.

PY - 1994/6/15

Y1 - 1994/6/15

N2 - The study was carried out to determine the urinary excretion of endothelin-1 (ET-1) in normal pregnancy and to define its possible role in mediating the renal response to aldosterone and arginine vasopressin (AVP). Measurements were performed in 12 healthy pregnant women serially in the 20th, 24th, 28th, 32nd and 36th weeks of pregnancy. Urinary ET-1, plasma and urinary aldosterone and AVP levels (RIA methods) as well as plasma and urine sodium, potassium, creatinine and osmolality were measured; creatinine clearance (Ccr), osmolar clearance (Cosm) and free water clearance (CH2O) calculated. Fractional sodium excretion (FENa), urine sodium/potassium ratio ( Na K) and transtubular potassium concentration gradient (TTKG) were also determined. It was demonstrated that urinary ET-1 excretion was higher in pregnant than in non-pregnant women and it increased further as the pregnancy progressed from 34.8 ± 4.0 pmol/day in week 20 to 44.1 ± 3.2 pmol/day in week 36 (P <0.01). Daily ET-1 excretion significantly correlated with AVP (r = 0.39, P <0.005) and aldosterone excretion (r = 0.62, P <0.0001). Furthermore, there was a significant positive relationship between ET-1 excretion and urine flow rate (r = 0.67, P <0.0001), CCR (r = 0.40, P <0.0025), Cosm (r = 0.58, P <0.001), sodium (r = 0.56, P <0.001) and potassium excretion (r = 0.42, P <0.001). However, such a relationship could not be established between ET-1 excretion and FENa, TTKG and Na K. It is concluded that the activated reninangiotensin-aldosterone system, the augmented AVP secretion and the reduced renal medullary tonicity might contribute to the increased renal ET-1 production in pregnancy, which might modulate the renal response to aldosterone and AVP.

AB - The study was carried out to determine the urinary excretion of endothelin-1 (ET-1) in normal pregnancy and to define its possible role in mediating the renal response to aldosterone and arginine vasopressin (AVP). Measurements were performed in 12 healthy pregnant women serially in the 20th, 24th, 28th, 32nd and 36th weeks of pregnancy. Urinary ET-1, plasma and urinary aldosterone and AVP levels (RIA methods) as well as plasma and urine sodium, potassium, creatinine and osmolality were measured; creatinine clearance (Ccr), osmolar clearance (Cosm) and free water clearance (CH2O) calculated. Fractional sodium excretion (FENa), urine sodium/potassium ratio ( Na K) and transtubular potassium concentration gradient (TTKG) were also determined. It was demonstrated that urinary ET-1 excretion was higher in pregnant than in non-pregnant women and it increased further as the pregnancy progressed from 34.8 ± 4.0 pmol/day in week 20 to 44.1 ± 3.2 pmol/day in week 36 (P <0.01). Daily ET-1 excretion significantly correlated with AVP (r = 0.39, P <0.005) and aldosterone excretion (r = 0.62, P <0.0001). Furthermore, there was a significant positive relationship between ET-1 excretion and urine flow rate (r = 0.67, P <0.0001), CCR (r = 0.40, P <0.0025), Cosm (r = 0.58, P <0.001), sodium (r = 0.56, P <0.001) and potassium excretion (r = 0.42, P <0.001). However, such a relationship could not be established between ET-1 excretion and FENa, TTKG and Na K. It is concluded that the activated reninangiotensin-aldosterone system, the augmented AVP secretion and the reduced renal medullary tonicity might contribute to the increased renal ET-1 production in pregnancy, which might modulate the renal response to aldosterone and AVP.

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KW - Renal functions

KW - Urinary endothelin-1

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