Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs

Gyorgy Andreka, Marton Vertesaljai, Gergely Szantho, Gusztav Font, Zsolt Piroth, Geza Fontos, Eszter D. Juhasz, Laszlo Szekely, Zsolt Szelid, Mark S. Turner, Houman Ashrafian, Michael P. Frenneaux, P. Andréka

Research output: Article

153 Citations (Scopus)

Abstract

Background: Ischaemic preconditioning results in a reduction in ischaemic-reperfusion injury to the heart. This beneficial effect is seen both with direct local preconditioning of the myocardium and with remote preconditioning of easily accessible distant non-vital limb tissue. Ischaemic postconditioning with a comparable sequence of brief periods of local ischaemia, when applied immediately after the ischaemic insult, confers benefits similar to preconditioning. Objective: To test the hypothesis that limb ischaemia induces remote postconditioning and hence reduces experimental myocardial infarct size in a validated swine model of acute myocardial infarction. Methods: Acute myocardial infarction was induced in 24 pigs with 90 min balloon inflations of the left anterior descending coronary artery. Remote ischaemic postconditioning was induced in 12 of the pigs by four 5 min cycles of blood pressure cuff inflation applied to the lower limb immediately after the balloon deflation. Infarct size was assessed by measuring 72 h creatinine kinase release, MRI scan and immunohistochemical analysis. Results: Area under the curve of creatinine kinase release was significantly reduced in the postconditioning group compared with the control group with a 26% reduction in the infarct size (p

Original languageEnglish
Pages (from-to)749-752
Number of pages4
JournalHeart
Volume93
Issue number6
DOIs
Publication statusPublished - jún. 2007

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Ischemic Postconditioning
Swine
Myocardial Infarction
Economic Inflation
Creatinine
Phosphotransferases
Ischemia
Extremities
Ischemic Preconditioning
Reperfusion Injury
Area Under Curve
Lower Extremity
Coronary Vessels
Myocardium
Magnetic Resonance Imaging
Blood Pressure
Control Groups

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs. / Andreka, Gyorgy; Vertesaljai, Marton; Szantho, Gergely; Font, Gusztav; Piroth, Zsolt; Fontos, Geza; Juhasz, Eszter D.; Szekely, Laszlo; Szelid, Zsolt; Turner, Mark S.; Ashrafian, Houman; Frenneaux, Michael P.; Andréka, P.

In: Heart, Vol. 93, No. 6, 06.2007, p. 749-752.

Research output: Article

Andreka, G, Vertesaljai, M, Szantho, G, Font, G, Piroth, Z, Fontos, G, Juhasz, ED, Szekely, L, Szelid, Z, Turner, MS, Ashrafian, H, Frenneaux, MP & Andréka, P 2007, 'Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs', Heart, vol. 93, no. 6, pp. 749-752. https://doi.org/10.1136/hrt.2006.114504
Andreka G, Vertesaljai M, Szantho G, Font G, Piroth Z, Fontos G et al. Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs. Heart. 2007 jún.;93(6):749-752. https://doi.org/10.1136/hrt.2006.114504
Andreka, Gyorgy ; Vertesaljai, Marton ; Szantho, Gergely ; Font, Gusztav ; Piroth, Zsolt ; Fontos, Geza ; Juhasz, Eszter D. ; Szekely, Laszlo ; Szelid, Zsolt ; Turner, Mark S. ; Ashrafian, Houman ; Frenneaux, Michael P. ; Andréka, P. / Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs. In: Heart. 2007 ; Vol. 93, No. 6. pp. 749-752.
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AU - Juhasz, Eszter D.

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AU - Szelid, Zsolt

AU - Turner, Mark S.

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AU - Andréka, P.

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