Remarkably reduced transplant-related complications by dibromomannitol non-myeloablative conditioning before allogeneic bone marrow transplantation in chronic myeloid leukemia

Anikó Barta, Róbert Dénes, Tamás Masszi, Péter Reményi, Árpád Bátai, Éva Torbágyi, Andrea Sipos, Lilla Lengyel, Katalin Jakab, Éva Gyódi, Marienn Réti, János Földi, Piroska Páldi-Haris, Manuel Avalos, Katalin Pálóczi, Sándorné Fekete, Judit Török, Izabella Hoffer, Judit Jakab, Gábor VáradiEndre Kelemen, Gyozo Petrányi

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Abstract

A non-myeloablative conditioning protocol containing dibromomannitol (DBM/cytosine arabinoside/cyclophosphamide) has been applied to 36 chronic myeloid leukemia (CML) patients followed by bone marrow transplantation (BMT) from sibling donors. Risk factors include: accelerated phase (10 patients), older age (17 patients over>40 years) and long interval between diagnosis and BMT (27 months on average). Severe mucositis did not occur. Venoocclusive liver disease was absent. Infectious complications were rare. Although grade II-IV acute graft-versus-host disease (GVHD) was present in 9 (25%) cases, there were only 2 serious (III-IV) ones. Chronic GVHD occurred in 25 (69%) cases, preceded by acute GVHD in 9 of the 25 affected patients. Early hematological relapse, 7-29 weeks after BMT, developed in 6 patients (17.6%). No relapse was noted in the completely chimeric patients, however molecular genetic residual disease was observed in 6 patients, in most of them after transient short-term mixed chimeric state. Overall actual survival rate is 83.3% for the 36 cases, and leukemia-free survival is 72.2% for the 34 engrafted patients.

Original languageEnglish
Pages (from-to)64-70
Number of pages7
JournalActa Haematologica
Volume105
Issue number2
DOIs
Publication statusPublished - júl. 18 2001

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ASJC Scopus subject areas

  • Hematology

Cite this

Barta, A., Dénes, R., Masszi, T., Reményi, P., Bátai, Á., Torbágyi, É., Sipos, A., Lengyel, L., Jakab, K., Gyódi, É., Réti, M., Földi, J., Páldi-Haris, P., Avalos, M., Pálóczi, K., Fekete, S., Török, J., Hoffer, I., Jakab, J., ... Petrányi, G. (2001). Remarkably reduced transplant-related complications by dibromomannitol non-myeloablative conditioning before allogeneic bone marrow transplantation in chronic myeloid leukemia. Acta Haematologica, 105(2), 64-70. https://doi.org/10.1159/000046536