Relevance of the genetic polymorphism of NOD1 in Chlamydia pneumoniae seropositive stroke patients

Z. Tiszlavicz, F. Somogyvári, Á K. Kocsis, Z. Szolnoki, L. K. Sztriha, Z. Kis, L. Vécsei, Y. Mándi

Research output: Article

11 Citations (Scopus)

Abstract

Background and purpose: Chronic infections with certain pathogens, such as Chlamydia pneumoniae, and genetic parameters that influence inflammatory reactions have been suggested to contribute to ischaemic stroke. NOD1 is a potent cytosolic receptor for C. pneumoniae. The aim of this study was to investigate the genetic polymorphism of NOD1 from the aspect of the development of stroke. Materials and methods: A total of 280 patients with ischaemic stroke were enrolled in the study; 150 healthy blood donors served as controls. The G796A (E266K) NOD1 polymorphism was determined by restriction fragment length polymorphism. Chlamydia pneumoniae seropositivity was tested by ELISA. Results: There was a significant difference in NOD1 G796A genotype distribution between the controls and the stroke patients with C. pneumoniae seropositivity. The AA homozygote and GA heterozygote mutant variants were detected in 16% (25 of 152) and in 50% (77 of 152) of the C. pneumoniae-positive stroke patients, as compared with 8% (6 of 84), and 28% (24 of 84), respectively, in the C. pneumoniae-positive healthy controls. (OR = 2.559; 95% CI = 1.105-6.517, P = 0.04 and OR = 2.567; 95% CI = 1.451-4.540 P < 0.001, respectively). The stroke patients with the large vessel pathology exhibited the highest frequency of the mutant allele A (51%). In contrast, amongst the C. pneumoniae-negative subjects, no difference in genotype frequency was observed between the stroke patients and the controls. Conclusion: Polymorphism in NOD1 G796A alone did not prove to be a risk factor for stroke in general, but in association with C. pneumoniae infection it appeared to be accompanied by an increased risk of the development of stroke.

Original languageEnglish
Pages (from-to)1224-1229
Number of pages6
JournalEuropean Journal of Neurology
Volume16
Issue number11
DOIs
Publication statusPublished - nov. 1 2009

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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