Relevance of defensin β-2 and α defensins (HNP1-3) in Alzheimer's disease

M. Szekeres, Eszter Ivitz, Zsolt Datki, J. Kálmán, M. Pákáski, Zoltán P. Várhelyi, P. Klivényi, Dénes Zadori, F. Somogyvári, Z. Szolnoki, L. Vécsei, Y. Mándi

Research output: Article

2 Citations (Scopus)

Abstract

The DEFB4 gene copy numbers were investigated in 206 AD patients and in 250 controls. The levels of the human defensin β-2 (hBD2) and α-defensins (HNP 1-3) in the sera and in the cerebrospinal fluid (CSF) of the patients and the controls were determined.Higher copy numbers of the DEFB4 gene was observed in AD patients as compared with the controls. The levels of hBD-2 and HNP 1-3 were significantly elevated in the sera and in the CSF of the AD patients. These data suggest that both defensin β-2 and α-defensins have potential role in the development of AD.

Original languageEnglish
Pages (from-to)342-345
Number of pages4
JournalPsychiatry Research
Volume239
DOIs
Publication statusPublished - máj. 30 2016

Fingerprint

Defensins
Gene Dosage
Cerebrospinal Fluid
Serum
Alzheimer disease, familial, type 3
human neutrophil peptide 1
human neutrophil peptide 3

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

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title = "Relevance of defensin β-2 and α defensins (HNP1-3) in Alzheimer's disease",
abstract = "The DEFB4 gene copy numbers were investigated in 206 AD patients and in 250 controls. The levels of the human defensin β-2 (hBD2) and α-defensins (HNP 1-3) in the sera and in the cerebrospinal fluid (CSF) of the patients and the controls were determined.Higher copy numbers of the DEFB4 gene was observed in AD patients as compared with the controls. The levels of hBD-2 and HNP 1-3 were significantly elevated in the sera and in the CSF of the AD patients. These data suggest that both defensin β-2 and α-defensins have potential role in the development of AD.",
keywords = "Antimicrobial peptides, Cerebrospinal fluid, Copy number polymorphism",
author = "M. Szekeres and Eszter Ivitz and Zsolt Datki and J. K{\'a}lm{\'a}n and M. P{\'a}k{\'a}ski and V{\'a}rhelyi, {Zolt{\'a}n P.} and P. Kliv{\'e}nyi and D{\'e}nes Zadori and F. Somogyv{\'a}ri and Z. Szolnoki and L. V{\'e}csei and Y. M{\'a}ndi",
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doi = "10.1016/j.psychres.2016.03.045",
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journal = "Psychiatry Research",
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T1 - Relevance of defensin β-2 and α defensins (HNP1-3) in Alzheimer's disease

AU - Szekeres, M.

AU - Ivitz, Eszter

AU - Datki, Zsolt

AU - Kálmán, J.

AU - Pákáski, M.

AU - Várhelyi, Zoltán P.

AU - Klivényi, P.

AU - Zadori, Dénes

AU - Somogyvári, F.

AU - Szolnoki, Z.

AU - Vécsei, L.

AU - Mándi, Y.

PY - 2016/5/30

Y1 - 2016/5/30

N2 - The DEFB4 gene copy numbers were investigated in 206 AD patients and in 250 controls. The levels of the human defensin β-2 (hBD2) and α-defensins (HNP 1-3) in the sera and in the cerebrospinal fluid (CSF) of the patients and the controls were determined.Higher copy numbers of the DEFB4 gene was observed in AD patients as compared with the controls. The levels of hBD-2 and HNP 1-3 were significantly elevated in the sera and in the CSF of the AD patients. These data suggest that both defensin β-2 and α-defensins have potential role in the development of AD.

AB - The DEFB4 gene copy numbers were investigated in 206 AD patients and in 250 controls. The levels of the human defensin β-2 (hBD2) and α-defensins (HNP 1-3) in the sera and in the cerebrospinal fluid (CSF) of the patients and the controls were determined.Higher copy numbers of the DEFB4 gene was observed in AD patients as compared with the controls. The levels of hBD-2 and HNP 1-3 were significantly elevated in the sera and in the CSF of the AD patients. These data suggest that both defensin β-2 and α-defensins have potential role in the development of AD.

KW - Antimicrobial peptides

KW - Cerebrospinal fluid

KW - Copy number polymorphism

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