Release of pancreatic polypeptide in humans by infusion of cholecystokinin

Janos Lonovics, Sergio Guzman, Peter Devitt, Kelly E. Hejtmancik, Robert L. Suddith, Phillip L. Rayford, James C. Thompson

Research output: Article

101 Citations (Scopus)


Plasma levels of pancreatic polypeptide were measured after a test meal and after infusion of graded doses of 99% pure cholecystokinin in 6 healthy volunteers. Initial attempts at sterilization of 99% pure cholecystokinin resulted in complete inactivation. Successful sterilization was accomplished by filtration by using specially treated silver-coated filters. Biologic activity of sterilized material was confirmed with cholecystokinin bioassay, and plasma levels of sterilized cholecystokinin achieved by exogenous infusions were measured with a specific cholecystokinin radioimmunoassay. Significant increases in plasma levels of pancreatic polypeptide were found with a test meal and with infusions of 0.25 and 0.5 μg/kg-hr of 99% pure cholecystokinin. Integrated values of pancreatic polypeptide released by the low-dose and the high-dose infusions of 99% pure cholecystokinin were 59% and 50% of that obtained by food, respectively. Integrated levels of cholecystokinin after 45 min of infusion of 0.25 μg/kg-hr were equal to those after a standard meal. Cholecystokinin, therefore, is an effective humoral releaser of pancreatic polypeptide in humans and may play an important role in the intestinal phase of release of pancreatic polypeptide.

Original languageEnglish
Pages (from-to)817-822
Number of pages6
Issue number5
Publication statusPublished - jan. 1 1980

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Lonovics, J., Guzman, S., Devitt, P., Hejtmancik, K. E., Suddith, R. L., Rayford, P. L., & Thompson, J. C. (1980). Release of pancreatic polypeptide in humans by infusion of cholecystokinin. Gastroenterology, 79(5), 817-822.