Regional gray matter reduction and theory of mind deficit in the early phase of schizophrenia: A voxel-based morphometric study

R. Herold, Á Feldmann, M. Simon, T. Tényi, F. Kövér, F. Nagy, E. Varga, S. Fekete

Research output: Article

52 Citations (Scopus)

Abstract

Objective: We tested the association between theory of mind (ToM) performance and structural changes in the brains of patients in the early course of schizophrenia. Method: Voxel-based morphometry (VBM) data of 18 patients with schizophrenia were compared with those of 21 controls. ToM skills were assessed by computerized faux pas (FP) tasks. Results: Patients with schizophrenia performed significantly worse in FP tasks than healthy subjects. VBM revealed significantly reduced gray matter density in certain frontal, temporal and subcortical regions in patients with schizophrenia. Poor FP performance of schizophrenics correlated with gray matter reduction in the left orbitofrontal cortex and right temporal pole. Conclusion: Our data indicate an association between poor ToM performance and regional gray matter reduction in the left orbitofrontal cortex and right temporal pole shortly after the onset of schizophrenia.

Original languageEnglish
Pages (from-to)199-208
Number of pages10
JournalActa Psychiatrica Scandinavica
Volume119
Issue number3
DOIs
Publication statusPublished - márc. 1 2009

ASJC Scopus subject areas

  • Psychiatry and Mental health

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