Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort

IDEFICS Consortium

Research output: Article

25 Citations (Scopus)

Abstract

OBJECTIVE: To establish age- and sex-specific reference values for serum leptin and adiponectin in normal-weight 3.0-8.9-year old European children.

SUBJECTS AND METHODS: Blood samples for hormone analysis were taken from 1338 children of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and infantS) study cohort. Only normal-weight children aged 3.0-8.9 years were included (n=539) in our analysis. Using the General Additive Model for Location Scale and Shape, age- and sex-specific percentiles were derived. The influence of under/overweight and obesity on the proposed reference curves based on normal-weight children was investigated in several sensitivity analyses using the sample without obese children (n=1015) and the whole study sample (n=1338).

RESULTS: There was a negative age trend of adiponectin blood levels and a positive trend of leptin levels in boys and girls. Percentiles derived for girls were generally higher than those obtained for boys. The corresponding age-specific differences of the 97th percentile ranged from -2.2 to 4.6 μg ml(-1) and from 2.2 to 4.8 ng ml(-1) for adiponectin and leptin, respectively.

CONCLUSIONS: According to our knowledge, these are the first reference values of leptin and adiponectin in prepubertal, normal-weight children. The presented adiponectin and leptin reference curves may allow for a more differentiated interpretation of children's hormone levels in epidemiological and clinical studies.

Original languageEnglish
Pages (from-to)S32-S38
JournalInternational Journal of Obesity
Volume38
DOIs
Publication statusPublished - szept. 1 2014

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Adiponectin
Leptin
Reference Values
Weights and Measures
Hormones
Life Style
Epidemiologic Studies
Cohort Studies
Obesity
Health
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{63c00a6ecffb42e8a8e1eaade8ce0bb6,
title = "Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort",
abstract = "OBJECTIVE: To establish age- and sex-specific reference values for serum leptin and adiponectin in normal-weight 3.0-8.9-year old European children.SUBJECTS AND METHODS: Blood samples for hormone analysis were taken from 1338 children of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and infantS) study cohort. Only normal-weight children aged 3.0-8.9 years were included (n=539) in our analysis. Using the General Additive Model for Location Scale and Shape, age- and sex-specific percentiles were derived. The influence of under/overweight and obesity on the proposed reference curves based on normal-weight children was investigated in several sensitivity analyses using the sample without obese children (n=1015) and the whole study sample (n=1338).RESULTS: There was a negative age trend of adiponectin blood levels and a positive trend of leptin levels in boys and girls. Percentiles derived for girls were generally higher than those obtained for boys. The corresponding age-specific differences of the 97th percentile ranged from -2.2 to 4.6 μg ml(-1) and from 2.2 to 4.8 ng ml(-1) for adiponectin and leptin, respectively.CONCLUSIONS: According to our knowledge, these are the first reference values of leptin and adiponectin in prepubertal, normal-weight children. The presented adiponectin and leptin reference curves may allow for a more differentiated interpretation of children's hormone levels in epidemiological and clinical studies.",
author = "{IDEFICS Consortium} and E. Erhardt and R. Foraita and I. Pigeot and G. Barba and T. Veidebaum and M. Tornaritis and N. Michels and G. Eiben and W. Ahrens and Moreno, {L. A.} and E. Kov{\'a}cs and D. Moln{\'a}r",
year = "2014",
month = "9",
day = "1",
doi = "10.1038/ijo.2014.133",
language = "English",
volume = "38",
pages = "S32--S38",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",

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TY - JOUR

T1 - Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort

AU - IDEFICS Consortium

AU - Erhardt, E.

AU - Foraita, R.

AU - Pigeot, I.

AU - Barba, G.

AU - Veidebaum, T.

AU - Tornaritis, M.

AU - Michels, N.

AU - Eiben, G.

AU - Ahrens, W.

AU - Moreno, L. A.

AU - Kovács, E.

AU - Molnár, D.

PY - 2014/9/1

Y1 - 2014/9/1

N2 - OBJECTIVE: To establish age- and sex-specific reference values for serum leptin and adiponectin in normal-weight 3.0-8.9-year old European children.SUBJECTS AND METHODS: Blood samples for hormone analysis were taken from 1338 children of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and infantS) study cohort. Only normal-weight children aged 3.0-8.9 years were included (n=539) in our analysis. Using the General Additive Model for Location Scale and Shape, age- and sex-specific percentiles were derived. The influence of under/overweight and obesity on the proposed reference curves based on normal-weight children was investigated in several sensitivity analyses using the sample without obese children (n=1015) and the whole study sample (n=1338).RESULTS: There was a negative age trend of adiponectin blood levels and a positive trend of leptin levels in boys and girls. Percentiles derived for girls were generally higher than those obtained for boys. The corresponding age-specific differences of the 97th percentile ranged from -2.2 to 4.6 μg ml(-1) and from 2.2 to 4.8 ng ml(-1) for adiponectin and leptin, respectively.CONCLUSIONS: According to our knowledge, these are the first reference values of leptin and adiponectin in prepubertal, normal-weight children. The presented adiponectin and leptin reference curves may allow for a more differentiated interpretation of children's hormone levels in epidemiological and clinical studies.

AB - OBJECTIVE: To establish age- and sex-specific reference values for serum leptin and adiponectin in normal-weight 3.0-8.9-year old European children.SUBJECTS AND METHODS: Blood samples for hormone analysis were taken from 1338 children of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and infantS) study cohort. Only normal-weight children aged 3.0-8.9 years were included (n=539) in our analysis. Using the General Additive Model for Location Scale and Shape, age- and sex-specific percentiles were derived. The influence of under/overweight and obesity on the proposed reference curves based on normal-weight children was investigated in several sensitivity analyses using the sample without obese children (n=1015) and the whole study sample (n=1338).RESULTS: There was a negative age trend of adiponectin blood levels and a positive trend of leptin levels in boys and girls. Percentiles derived for girls were generally higher than those obtained for boys. The corresponding age-specific differences of the 97th percentile ranged from -2.2 to 4.6 μg ml(-1) and from 2.2 to 4.8 ng ml(-1) for adiponectin and leptin, respectively.CONCLUSIONS: According to our knowledge, these are the first reference values of leptin and adiponectin in prepubertal, normal-weight children. The presented adiponectin and leptin reference curves may allow for a more differentiated interpretation of children's hormone levels in epidemiological and clinical studies.

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U2 - 10.1038/ijo.2014.133

DO - 10.1038/ijo.2014.133

M3 - Article

C2 - 25219410

AN - SCOPUS:84930800726

VL - 38

SP - S32-S38

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -