Reelin-expressing neurons in the postnatal and adult human hippocampal formation

H. Ábrahám, Gundela Meyer

Research output: Article

68 Citations (Scopus)

Abstract

Reelin plays a major role in the development of laminated brain structures. In the developing neocortex and hippocampus, Reelin is secreted by Cajal-Retzius cells in the marginal zone. In the present report, we characterize Reelin-immunoreactive neurons in the perinatal and adult human hippocampal formation. Two main populations of cells are described: Cajal-Retzius cells and interneurons. Cajal-Retzius cells are defined as neurons that coexpress Reelin and p73, a nuclear protein of the p53 family. Colocalization experiments of p73 with calcium-binding proteins indicate that most Cajal-Retzius cells express calretinin, but not calbindin. Cajal-Retzius cell density decreases dramatically during the postnatal period, although a few Reelin/p73-positive neurons are still found in the adult. At birth, Reelin-positive, p73-negative neurons are present in all layers of the hippocampal formation. Their morphology and localization indicate that they belong to a heterogeneous population of interneurons. They are numerous in the strata lacunosum-moleculare and radiatum of CA1-CA3, in the hilus, and in the molecular layer of the dentate gyrus, but less common in stratum oriens and alveus, and rare in the principal cell layers. Subpopulations of Reelin-positive interneurons express calretinin or calbindin. The packing density of Reelin-positive cells decreases postnatally, which may be related to the disappearance of Cajal-Retzius cells and to the growth of the hippocampal formation. The presence of Reelin-immunoreactive cells in the adult hippocampal formation indicates that Reelin is not restricted to development but that it may have additional functions in adult life.

Original languageEnglish
Pages (from-to)715-727
Number of pages13
JournalHippocampus
Volume13
Issue number6
DOIs
Publication statusPublished - 2003

Fingerprint

Hippocampus
Neurons
Interneurons
Calbindin 2
Calbindins
Calcium-Binding Proteins
Neocortex
Dentate Gyrus
Nuclear Proteins
Population
Cell Count
Parturition
Brain
Growth

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Reelin-expressing neurons in the postnatal and adult human hippocampal formation. / Ábrahám, H.; Meyer, Gundela.

In: Hippocampus, Vol. 13, No. 6, 2003, p. 715-727.

Research output: Article

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