Reduced serum dopamine-β-hydroxylase activity in paranoid schizophrenics

M. Arato, G. Bagdy, F. Blumel

Research output: Article

21 Citations (Scopus)

Abstract

The serum dopamine-beta-hydroxylase activity of 134 carefully selected paranoid schizophrenic patients was compared with that of 118 normal controls. Significantly reduced serum DBH activity found in the schizophrenic group in comparison to the control group could not be brought into relationship withe the patient's age, nor with neuroleptic treatment. Manic depressive patients showed values similar to the normal control group. It is discussed that mainly genetically determined low serum DBH activity may be related to the hyperdopaminergic pathomechanism of paranoid schizophrenia.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalPharmacopsychiatria
Volume6
Issue number1
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Medicine(all)

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