Recommendations for identifying Crohn's disease patients with poor prognosis

P. Miheller, Lajos S. Kiss, Mark Juhasz, Michael Mandel, P. Lakatos

Research output: Article

12 Citations (Scopus)

Abstract

Clinical presentation at diagnosis and the disease course of Crohn's disease is heterogeneous and variable over time. The majority of patients with Crohn's disease will develop at least one stricturing or perforating complication requiring surgery during follow-up. New data support a change in the natural history of the disease associated with the advent of biologicals and tailored treatment strategy. Therefore, it is important to identify patients at risk for disease progression as soon as possible. In recent years, much emphasis has been placed on determining important predictive factors. Complex evaluation of factors such as clinical and endoscopic presentation, fecal, serological and routine laboratory tests, and genetic factors is needed. This review summarizes the available evidence and will hopefully assist clinicians when choosing a treatment strategy in everyday practice.

Original languageEnglish
Pages (from-to)65-76
Number of pages12
JournalExpert Review of Clinical Immunology
Volume9
Issue number1
DOIs
Publication statusPublished - jan. 2013

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Crohn Disease
Disease Progression
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Recommendations for identifying Crohn's disease patients with poor prognosis. / Miheller, P.; Kiss, Lajos S.; Juhasz, Mark; Mandel, Michael; Lakatos, P.

In: Expert Review of Clinical Immunology, Vol. 9, No. 1, 01.2013, p. 65-76.

Research output: Article

Miheller, P. ; Kiss, Lajos S. ; Juhasz, Mark ; Mandel, Michael ; Lakatos, P. / Recommendations for identifying Crohn's disease patients with poor prognosis. In: Expert Review of Clinical Immunology. 2013 ; Vol. 9, No. 1. pp. 65-76.
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