Recipient and donor JAK2 46/1 haplotypes are associated with acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation

Katalin Balassa, Tunde Krahling, Peter Remenyi, Arpad Batai, Andras Bors, Katalin Piroska Kiss, Eva Torbagyi, Laszlo Gopcsa, Lilla Lengyel, Aniko Barta, Gergely Varga, A. Tordai, T. Masszi, H. Andrikovics

Research output: Article

4 Citations (Scopus)

Abstract

Several genetic polymorphisms have been implicated to affect the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT). The role of cytokines in acute graft-versus-host disease (aGvHD) is well established and many of the involved cytokines signal through the Janus kinase (JAK) pathways. In this study, we assessed the association of recipient and donor JAK2 46/1 haplotypes and allo-HSCT outcome in a cohort of 124 acute myeloid leukemia patients. Both, recipient and donor 46/1 haplotypes significantly affected aGvHD grades II–IV development (p = 0.006 and p = 0.031, respectively), furthermore the influence of the haplotypes seemed to be additive. In multivariate analyses the recipient haplotype remained independently related (p = 0.012) to aGvHD, while the donor not (p = 0.08). We observed significantly less relapses among haplotype carriers (p = 0.004), but overall survival did not differ (p = 0.732). Our findings suggest that recipient and donor JAK2 46/1 haplotypes might be involved in the regulation of aGvHD.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalLeukemia and Lymphoma
DOIs
Publication statusAccepted/In press - júl. 7 2016

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Hematopoietic Stem Cell Transplantation
Graft vs Host Disease
Haplotypes
Tissue Donors
Cytokines
Janus Kinases
Genetic Polymorphisms
Acute Myeloid Leukemia
Multivariate Analysis
Recurrence
Survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Recipient and donor JAK2 46/1 haplotypes are associated with acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. / Balassa, Katalin; Krahling, Tunde; Remenyi, Peter; Batai, Arpad; Bors, Andras; Kiss, Katalin Piroska; Torbagyi, Eva; Gopcsa, Laszlo; Lengyel, Lilla; Barta, Aniko; Varga, Gergely; Tordai, A.; Masszi, T.; Andrikovics, H.

In: Leukemia and Lymphoma, 07.07.2016, p. 1-8.

Research output: Article

Balassa, Katalin ; Krahling, Tunde ; Remenyi, Peter ; Batai, Arpad ; Bors, Andras ; Kiss, Katalin Piroska ; Torbagyi, Eva ; Gopcsa, Laszlo ; Lengyel, Lilla ; Barta, Aniko ; Varga, Gergely ; Tordai, A. ; Masszi, T. ; Andrikovics, H. / Recipient and donor JAK2 46/1 haplotypes are associated with acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. In: Leukemia and Lymphoma. 2016 ; pp. 1-8.
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abstract = "Several genetic polymorphisms have been implicated to affect the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT). The role of cytokines in acute graft-versus-host disease (aGvHD) is well established and many of the involved cytokines signal through the Janus kinase (JAK) pathways. In this study, we assessed the association of recipient and donor JAK2 46/1 haplotypes and allo-HSCT outcome in a cohort of 124 acute myeloid leukemia patients. Both, recipient and donor 46/1 haplotypes significantly affected aGvHD grades II–IV development (p = 0.006 and p = 0.031, respectively), furthermore the influence of the haplotypes seemed to be additive. In multivariate analyses the recipient haplotype remained independently related (p = 0.012) to aGvHD, while the donor not (p = 0.08). We observed significantly less relapses among haplotype carriers (p = 0.004), but overall survival did not differ (p = 0.732). Our findings suggest that recipient and donor JAK2 46/1 haplotypes might be involved in the regulation of aGvHD.",
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AU - Balassa, Katalin

AU - Krahling, Tunde

AU - Remenyi, Peter

AU - Batai, Arpad

AU - Bors, Andras

AU - Kiss, Katalin Piroska

AU - Torbagyi, Eva

AU - Gopcsa, Laszlo

AU - Lengyel, Lilla

AU - Barta, Aniko

AU - Varga, Gergely

AU - Tordai, A.

AU - Masszi, T.

AU - Andrikovics, H.

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