Radiation myelopathy with partial functional recovery: PET evidence of long-term increased metabolic activity of the spinal cord

Olga Ésik, Miklós Emri, Márta Csornai, Miklós Kásler, Mária Godény, Lajos Trón

Research output: Article

27 Citations (Scopus)

Abstract

Postoperative telecobalt irradiation was performed with a biologically effective extrapolated response dose of 165 Gy2 delivered to the spinal cord of a papillary thyroid cancer patient. Incomplete cervical transection developed, followed by a gradual functional improvement, which is still continuing 8 years after radiotherapy. Between the 6th and 8th years of the clinical course, positron emission tomography investigations demonstrated an increased 18F-deoxyglucose accumulation and 15O-butanol perfusion, but negligible 11C-methionine uptake in the irradiated spinal cord segment. We suggest that the increased metabolism and perfusion, and the lack of detectable protein synthesis may be related to the increased energy demands of action potential conduction, due to the higher than normal density of sodium channels along demyelinated axons displaying restored conduction.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalJournal of the Neurological Sciences
Volume163
Issue number1
DOIs
Publication statusPublished - febr. 1 1999

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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