Radiation induced degradation of ciprofloxacin and norfloxacin: Kinetics and product analysis

Anna Tegze, Gyuri Sági, Krisztina Kovács, Tünde Tóth, E. Takács, L. Wojnárovits

Research output: Article

1 Citation (Scopus)

Abstract

Ionizing radiation induced degradation of two fluoroquinolone antibiotics, ciprofloxacin and norfloxacin was investigated in 0.1 mmol dm –3 aqueous solutions. The rate constants, directly determined by pulse radiolysis, were 7.2 × 10 9 mol –1 dm 3 s –1 and 5.4 × 10 9 mol –1 dm 3 s –1 for OH reaction and 8.2 × 10 9 mol –1 dm 3 s –1 and 7.3 × 10 9 mol –1 dm 3 s –1 for hydrated electron reaction with ciprofloxacin and norfloxacin, respectively. Absorption bands of several transient intermediates were observed on the pulse radiolysis spectra. For end product characterization samples were irradiated in a 60 Co–γ irradiation chamber, they were analyzed by taking the UV–Vis spectra and by LC separation with MS detection. Based on their structures, most of the products presumably had lost their antibacterial activity. For both compounds products reflecting reaction on the quinolone part (hydroxylated molecules) or on the piperazinyl moiety (desethylene derivatives) were observed.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalRadiation Physics and Chemistry
Volume158
DOIs
Publication statusPublished - máj. 1 2019

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degradation
radiolysis
kinetics
radiation
products
antibiotics
pulses
ionizing radiation
chambers
aqueous solutions
absorption spectra
irradiation
molecules
electrons

ASJC Scopus subject areas

  • Radiation

Cite this

Radiation induced degradation of ciprofloxacin and norfloxacin : Kinetics and product analysis. / Tegze, Anna; Sági, Gyuri; Kovács, Krisztina; Tóth, Tünde; Takács, E.; Wojnárovits, L.

In: Radiation Physics and Chemistry, Vol. 158, 01.05.2019, p. 68-75.

Research output: Article

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