Quantitative EEG abnormalities in persons with "pure" epileptic predisposition without epilepsy: A low resolution electromagnetic tomography (LORETA) study

S. Puskás, M. Bessenyei, I. Fekete, K. Hollódy, B. Clemens

Research output: Article

4 Citations (Scopus)

Abstract

Objective: Epileptic predisposition means genetically determined, increased seizure susceptibility. Neurophysiological evaluation of this condition is still lacking. In order to investigate " pure epileptic predisposition" (without epilepsy) in this pilot study the authors prospectively recruited ten persons who displayed generalized tonic-clonic seizures precipitated by 24 or more hours of sleep deprivation but were healthy in any other respects. Methods: 21-channel EEGs were recorded in the morning, in the waking state, after a night of sufficient sleep in the interictal period. For each person, a total of 120. s artifact-free EEG was processed to low resolution electromagnetic tomography (LORETA) analysis. LORETA activity (Ampers/meters squared) was computed for 2394 voxels, 19 active electrodes and 1. Hz very narrow bands from 1 to 25. Hz. The data were compressed into four frequency bands (δ: 0.5-4.0. Hz, θ: 4.5-8.0. Hz, α: 8.5-12.0. Hz, β: 12.5-25.0. Hz) and projected onto the MRI figures of a digitized standard brain atlas. The band-related LORETA results were compared to those of ten, age- and sex-matched healthy persons using independent t-tests. p<0.01 differences were accepted as statistically significant. Results: Statistically significant decrease of α activity was found in widespread, medial and lateral parts of the cortex above the level of the basal ganglia. Maximum α decrease and statistically significant β decrease were found in the left precuneus. Statistically not significant differences were δ increase in the medial-basal frontal area and θ increase in the same area and in the basal temporal area. Discussion: The significance of α decrease in the patient group remains enigmatic β decrease presumably reflects non-specific dysfunction of the cortex. Prefrontal δ and θ increase might have biological meaning despite the lack of statistical significance: these findings are topographically similar to those reported in idiopathic generalized epilepsy in previous investigations. Significance: Quantitative EEG characteristics of the genetically determined epilepsy predisposition were given in terms of frequency bands and anatomical distribution.

Original languageEnglish
Pages (from-to)94-100
Number of pages7
JournalEpilepsy Research
Volume91
Issue number1
DOIs
Publication statusPublished - szept. 1 2010

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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