Protein expression differences between lung adenocarcinoma and squamous cell carcinoma with brain metastasis

Katalin Fábián, Zsuzsanna Németh, József Furák, László Tiszlavicz, Judit Pápay, Tibor Krenács, József Tímár, Judit Moldvay

Research output: Article

5 Citations (Scopus)

Abstract

Aim: We investigated tissue biomarkers in non-small cell lung cancer (NSCLC) to find indicators of brain metastasis and peritumoral brain edema. Patients and Methods: Fifty-two cases were studied out of which 26 had corresponding brain metastatic tissue. Clinicopathological characteristics of tumors were correlated with biomarkers of cell adhesion, cell growth, cell cycle and apoptosis regulation that were previously immunohistochemically studied but never analyzed separately according to histological subgroups, gender and smoking history. Results: Increased collagen XVII in adenocarcinoma (ADC) and increased caspase-9, CD44v6, and decreased cellular apoptosis susceptibility protein (CAS) and Ki-67 in squamous cell carcinoma (SCC) correlated significantly with brain metastasis. Increased β-catenin, E-cadherin and decreased caspase-9 expression in primary SCC, and decreased CD44v6 expression in brain metastatic SCC tissues showed a significant correlation with the extent of peritumoral brain edema. Positive correlation between smoking and biomarker expression could be observed in metastatic ADCs with p16 and caspase-8, while-negative correlation was found in SCC without brain metastasis with caspase-3, and in SCC with brain metastasis with p27. Conclusion: Our results highlight the importance of separate analysis of biomarker expression in histological subtypes of NSCLC.

Original languageEnglish
Pages (from-to)5593-5597
Number of pages5
JournalAnticancer Research
Volume34
Issue number10
Publication statusPublished - okt. 1 2014

Fingerprint

Squamous Cell Carcinoma
Neoplasm Metastasis
Brain
Biomarkers
Proteins
Caspase 9
Brain Edema
Cellular Apoptosis Susceptibility Protein
Non-Small Cell Lung Carcinoma
Smoking
Catenins
Caspase 8
Cadherins
Cell Adhesion
Caspase 3
Adenocarcinoma of lung
Cell Cycle
Adenocarcinoma
History
Apoptosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Protein expression differences between lung adenocarcinoma and squamous cell carcinoma with brain metastasis. / Fábián, Katalin; Németh, Zsuzsanna; Furák, József; Tiszlavicz, László; Pápay, Judit; Krenács, Tibor; Tímár, József; Moldvay, Judit.

In: Anticancer Research, Vol. 34, No. 10, 01.10.2014, p. 5593-5597.

Research output: Article

Fábián, Katalin ; Németh, Zsuzsanna ; Furák, József ; Tiszlavicz, László ; Pápay, Judit ; Krenács, Tibor ; Tímár, József ; Moldvay, Judit. / Protein expression differences between lung adenocarcinoma and squamous cell carcinoma with brain metastasis. In: Anticancer Research. 2014 ; Vol. 34, No. 10. pp. 5593-5597.
@article{11e30679e8b04a1790d5139099b8defc,
title = "Protein expression differences between lung adenocarcinoma and squamous cell carcinoma with brain metastasis",
abstract = "Aim: We investigated tissue biomarkers in non-small cell lung cancer (NSCLC) to find indicators of brain metastasis and peritumoral brain edema. Patients and Methods: Fifty-two cases were studied out of which 26 had corresponding brain metastatic tissue. Clinicopathological characteristics of tumors were correlated with biomarkers of cell adhesion, cell growth, cell cycle and apoptosis regulation that were previously immunohistochemically studied but never analyzed separately according to histological subgroups, gender and smoking history. Results: Increased collagen XVII in adenocarcinoma (ADC) and increased caspase-9, CD44v6, and decreased cellular apoptosis susceptibility protein (CAS) and Ki-67 in squamous cell carcinoma (SCC) correlated significantly with brain metastasis. Increased β-catenin, E-cadherin and decreased caspase-9 expression in primary SCC, and decreased CD44v6 expression in brain metastatic SCC tissues showed a significant correlation with the extent of peritumoral brain edema. Positive correlation between smoking and biomarker expression could be observed in metastatic ADCs with p16 and caspase-8, while-negative correlation was found in SCC without brain metastasis with caspase-3, and in SCC with brain metastasis with p27. Conclusion: Our results highlight the importance of separate analysis of biomarker expression in histological subtypes of NSCLC.",
keywords = "Brain metastasis, Caspase, CD44v6, Gender differences, Immunohistochemistry, Lung cancer, Peritumoral edema, Smoking",
author = "Katalin F{\'a}bi{\'a}n and Zsuzsanna N{\'e}meth and J{\'o}zsef Fur{\'a}k and L{\'a}szl{\'o} Tiszlavicz and Judit P{\'a}pay and Tibor Kren{\'a}cs and J{\'o}zsef T{\'i}m{\'a}r and Judit Moldvay",
year = "2014",
month = "10",
day = "1",
language = "English",
volume = "34",
pages = "5593--5597",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "10",

}

TY - JOUR

T1 - Protein expression differences between lung adenocarcinoma and squamous cell carcinoma with brain metastasis

AU - Fábián, Katalin

AU - Németh, Zsuzsanna

AU - Furák, József

AU - Tiszlavicz, László

AU - Pápay, Judit

AU - Krenács, Tibor

AU - Tímár, József

AU - Moldvay, Judit

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Aim: We investigated tissue biomarkers in non-small cell lung cancer (NSCLC) to find indicators of brain metastasis and peritumoral brain edema. Patients and Methods: Fifty-two cases were studied out of which 26 had corresponding brain metastatic tissue. Clinicopathological characteristics of tumors were correlated with biomarkers of cell adhesion, cell growth, cell cycle and apoptosis regulation that were previously immunohistochemically studied but never analyzed separately according to histological subgroups, gender and smoking history. Results: Increased collagen XVII in adenocarcinoma (ADC) and increased caspase-9, CD44v6, and decreased cellular apoptosis susceptibility protein (CAS) and Ki-67 in squamous cell carcinoma (SCC) correlated significantly with brain metastasis. Increased β-catenin, E-cadherin and decreased caspase-9 expression in primary SCC, and decreased CD44v6 expression in brain metastatic SCC tissues showed a significant correlation with the extent of peritumoral brain edema. Positive correlation between smoking and biomarker expression could be observed in metastatic ADCs with p16 and caspase-8, while-negative correlation was found in SCC without brain metastasis with caspase-3, and in SCC with brain metastasis with p27. Conclusion: Our results highlight the importance of separate analysis of biomarker expression in histological subtypes of NSCLC.

AB - Aim: We investigated tissue biomarkers in non-small cell lung cancer (NSCLC) to find indicators of brain metastasis and peritumoral brain edema. Patients and Methods: Fifty-two cases were studied out of which 26 had corresponding brain metastatic tissue. Clinicopathological characteristics of tumors were correlated with biomarkers of cell adhesion, cell growth, cell cycle and apoptosis regulation that were previously immunohistochemically studied but never analyzed separately according to histological subgroups, gender and smoking history. Results: Increased collagen XVII in adenocarcinoma (ADC) and increased caspase-9, CD44v6, and decreased cellular apoptosis susceptibility protein (CAS) and Ki-67 in squamous cell carcinoma (SCC) correlated significantly with brain metastasis. Increased β-catenin, E-cadherin and decreased caspase-9 expression in primary SCC, and decreased CD44v6 expression in brain metastatic SCC tissues showed a significant correlation with the extent of peritumoral brain edema. Positive correlation between smoking and biomarker expression could be observed in metastatic ADCs with p16 and caspase-8, while-negative correlation was found in SCC without brain metastasis with caspase-3, and in SCC with brain metastasis with p27. Conclusion: Our results highlight the importance of separate analysis of biomarker expression in histological subtypes of NSCLC.

KW - Brain metastasis

KW - Caspase

KW - CD44v6

KW - Gender differences

KW - Immunohistochemistry

KW - Lung cancer

KW - Peritumoral edema

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=84917695042&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84917695042&partnerID=8YFLogxK

M3 - Article

C2 - 25275061

AN - SCOPUS:84917695042

VL - 34

SP - 5593

EP - 5597

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 10

ER -