Among biomolecules, proteins fulfil the most diverse roles. Recent advances in NMR-spectroscopy demonstrate that these molecules can be characterized by motions on a wide range of time scales, and besides their three-dimensional (3D) structures, dynamics is also fundamental to truly understand their biological activity. The present review focuses on NMR techniques suitable to assess the internal dynamics of proteins from picoseconds to minutes. After a brief introduction of protein motions and different techniques used to capture them, we describe the dynamical aspects of a diverse set of NMR observables in detail. We also present some examples of investigations on various systems aimed to understand Dynamics-Structure-Activity Relationships (DSARs) of proteins.
|Number of pages||41|
|Journal||Annual Reports on NMR Spectroscopy|
|Publication status||Published - okt. 15 2010|
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics