Protective effect of Cassia fistula fruit extract on bromobenzene-induced nephrotoxicity in mice

Heibatullah Kalantari, Mohammadtaha Jalali, Amir Jalali, Abobakr Salimi, Foad Alhalvachi, Balazs Varga, Bela Juhasz, Anita Jakab, Adam Kemeny-Beke, Rudolf Gesztelyi, Arpad Tosaki, Judit Zsuga

Research output: Article

11 Citations (Scopus)

Abstract

The efficacy of a crude hydro-alcoholic extract of Cassia fistula (golden shower tree) fruit to protect the kidney against bromobenzene-induced toxicity was studied. Negative control mice received normal saline; positive control mice were given 460 mg/kg of bromobenzene; Cassia fistula treated mice received 200, 400, 600 and 800 mg/kg of Cassia fistula fruit extract followed by 460 mg/kg bromobenzene (daily by oral gavage for 10 days). On the 11th day, the mice were sacrificed, blood samples were obtained to assess blood urea nitrogen (BUN) and creatinine levels, and kidneys were removed for histological examination. We found that bromobenzene induced significant nephrotoxicity reflected by an increase in levels of BUN and creatinine that was dose dependently prevented by the Cassia fistula fruit extract. The nephroprotective effect of the Cassia fistula fruit extract was confirmed by the histological examination of the kidneys. To the best of our knowledge, this is the first study to demonstrate the protective effect of Cassia fistula in nephrotoxicity.

Original languageEnglish
Pages (from-to)1710-1715
Number of pages6
JournalHuman and Experimental Toxicology
Volume30
Issue number10
DOIs
Publication statusPublished - okt. 1 2011

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ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Kalantari, H., Jalali, M., Jalali, A., Salimi, A., Alhalvachi, F., Varga, B., Juhasz, B., Jakab, A., Kemeny-Beke, A., Gesztelyi, R., Tosaki, A., & Zsuga, J. (2011). Protective effect of Cassia fistula fruit extract on bromobenzene-induced nephrotoxicity in mice. Human and Experimental Toxicology, 30(10), 1710-1715. https://doi.org/10.1177/0960327110396532