Progressive systemic sclerosis-from the molecular background to innovative therapies

Peter Szodoray, E. Kiss

Research output: Article

1 Citation (Scopus)

Abstract

Systemic sclerosis (SSc) is a complex autoimmune disorder. The cornerstones of the pathogenesis are vascular damage, fibrogenesis and various cellular and humoral autoimmune processes. The aim of the present review is to describe pathogenic steps, leading to the hallmark clinical picture of SSc. Indeed, numerous therapeutical approaches have been tested/are in use, directed towards vascular damage, fibrogenesis, as well as autoimmune processes in order to decelerate the progression of the disease. These therapies are also discussed in the review. Finally, we described certain novel immune-modulating possibilities, namely autologous stemcell transplantation and extracorporeal photochemotherapy.

Original languageEnglish
Pages (from-to)521-525
Number of pages5
JournalFrontiers in bioscience (Elite edition)
Volume2 E
Issue number2
Publication statusPublished - jan. 1 2010

Fingerprint

Diffuse Scleroderma
Investigational Therapies
Systemic Scleroderma
Blood Vessels
Photopheresis
Autologous Transplantation
Disease Progression
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

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