Intrapulmonális metasztázisok prognosztikai jelentösége operált tüdörákos esetekben.

Tamás Szöke, Imre Troján, József Furák, László Tiszlavicz, Adám Balogh

Research output: Article

Abstract

OBJECTIVE: The aim of this retrospective study was to establish the prognosis in lung tumour cases in which resection was followed by synchronous or metachronous intrapulmonary metastasis. METHODS: Between 1990 and 1999, 857 patients were operated on for primary lung cancer. Intrapulmonary metastases were observed in 21 patients. 11 cases were in stage III/B (on the basis of T4), and 10 were in stage IV (on the basis of M1). The histologic distribution of the primary tumours was 7 squamous cell carcinomas, 11 adenocarcinomas, 2 large cell carcinomas and 1 carcinoid. In 8 patients, histology demonstrated N1 or N2 lymph node metastasis. In 4 cases, there were more than one metastases. RESULTS: The 5-year survival was 21%, and the mean survival time (MST) was 29.5 months. For both the 5-year survival rate and MST, there was significant difference between the lymph node negative (N0) and lymph node positive (N1/N2) patients (N-: 30.7%, N+: 0%, p=0.017, MST: N-: 38.3 months, N+: 10.5 months, p=0.014), according to the stage (III/B: 30%, IV: 11.1%, p=0.025, III/B: 40.1 months, IV: 17.8 months, p=0.04) and the number of metastases (1 metastasis: 26.6%, more than 1 metastasis: 0%, p=0.036, 1 metastasis: 35.2 months, more than 1 metastasis: 8.5 months, p=0.045). No significant difference was detected on the basis of histological type, pleural, vascular and lymphatic invasion. In patients where 1 metastasis was found within one lobe and there were no lymph node metastases, the 5-year survival rate was 42.8% and MST was 49 months. The complication rate was 28.5% and the 30-day mortality was 4.7% (1 patient). Reoperation was performed in 1 case, for thoracic wall haematoma. CONCLUSION: Primary lung tumours giving intrapulmonary metastases, under certain conditions (lymph node negativity, 1 metastasis in the same lobe), can be operated on with good survival possibilities.

Original languageHungarian
Pages (from-to)397-401
Number of pages5
JournalMagyar Onkologia
Volume47
Issue number4
Publication statusPublished - 2003

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Lung Neoplasms
Neoplasm Metastasis
Survival Rate
Lymph Nodes
Large Cell Carcinoma
Neoplasms
Lung
Survival
Carcinoid Tumor
Thoracic Wall
Reoperation
Hematoma
Blood Vessels
Squamous Cell Carcinoma
Histology
Adenocarcinoma
Retrospective Studies
Mortality

ASJC Scopus subject areas

  • Cancer Research

Cite this

Intrapulmonális metasztázisok prognosztikai jelentösége operált tüdörákos esetekben. / Szöke, Tamás; Troján, Imre; Furák, József; Tiszlavicz, László; Balogh, Adám.

In: Magyar Onkologia, Vol. 47, No. 4, 2003, p. 397-401.

Research output: Article

Szöke, T, Troján, I, Furák, J, Tiszlavicz, L & Balogh, A 2003, 'Intrapulmonális metasztázisok prognosztikai jelentösége operált tüdörákos esetekben.', Magyar Onkologia, vol. 47, no. 4, pp. 397-401.
Szöke, Tamás ; Troján, Imre ; Furák, József ; Tiszlavicz, László ; Balogh, Adám. / Intrapulmonális metasztázisok prognosztikai jelentösége operált tüdörákos esetekben. In: Magyar Onkologia. 2003 ; Vol. 47, No. 4. pp. 397-401.
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title = "Intrapulmon{\'a}lis metaszt{\'a}zisok prognosztikai jelent{\"o}s{\'e}ge oper{\'a}lt t{\"u}d{\"o}r{\'a}kos esetekben.",
abstract = "OBJECTIVE: The aim of this retrospective study was to establish the prognosis in lung tumour cases in which resection was followed by synchronous or metachronous intrapulmonary metastasis. METHODS: Between 1990 and 1999, 857 patients were operated on for primary lung cancer. Intrapulmonary metastases were observed in 21 patients. 11 cases were in stage III/B (on the basis of T4), and 10 were in stage IV (on the basis of M1). The histologic distribution of the primary tumours was 7 squamous cell carcinomas, 11 adenocarcinomas, 2 large cell carcinomas and 1 carcinoid. In 8 patients, histology demonstrated N1 or N2 lymph node metastasis. In 4 cases, there were more than one metastases. RESULTS: The 5-year survival was 21{\%}, and the mean survival time (MST) was 29.5 months. For both the 5-year survival rate and MST, there was significant difference between the lymph node negative (N0) and lymph node positive (N1/N2) patients (N-: 30.7{\%}, N+: 0{\%}, p=0.017, MST: N-: 38.3 months, N+: 10.5 months, p=0.014), according to the stage (III/B: 30{\%}, IV: 11.1{\%}, p=0.025, III/B: 40.1 months, IV: 17.8 months, p=0.04) and the number of metastases (1 metastasis: 26.6{\%}, more than 1 metastasis: 0{\%}, p=0.036, 1 metastasis: 35.2 months, more than 1 metastasis: 8.5 months, p=0.045). No significant difference was detected on the basis of histological type, pleural, vascular and lymphatic invasion. In patients where 1 metastasis was found within one lobe and there were no lymph node metastases, the 5-year survival rate was 42.8{\%} and MST was 49 months. The complication rate was 28.5{\%} and the 30-day mortality was 4.7{\%} (1 patient). Reoperation was performed in 1 case, for thoracic wall haematoma. CONCLUSION: Primary lung tumours giving intrapulmonary metastases, under certain conditions (lymph node negativity, 1 metastasis in the same lobe), can be operated on with good survival possibilities.",
author = "Tam{\'a}s Sz{\"o}ke and Imre Troj{\'a}n and J{\'o}zsef Fur{\'a}k and L{\'a}szl{\'o} Tiszlavicz and Ad{\'a}m Balogh",
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T1 - Intrapulmonális metasztázisok prognosztikai jelentösége operált tüdörákos esetekben.

AU - Szöke, Tamás

AU - Troján, Imre

AU - Furák, József

AU - Tiszlavicz, László

AU - Balogh, Adám

PY - 2003

Y1 - 2003

N2 - OBJECTIVE: The aim of this retrospective study was to establish the prognosis in lung tumour cases in which resection was followed by synchronous or metachronous intrapulmonary metastasis. METHODS: Between 1990 and 1999, 857 patients were operated on for primary lung cancer. Intrapulmonary metastases were observed in 21 patients. 11 cases were in stage III/B (on the basis of T4), and 10 were in stage IV (on the basis of M1). The histologic distribution of the primary tumours was 7 squamous cell carcinomas, 11 adenocarcinomas, 2 large cell carcinomas and 1 carcinoid. In 8 patients, histology demonstrated N1 or N2 lymph node metastasis. In 4 cases, there were more than one metastases. RESULTS: The 5-year survival was 21%, and the mean survival time (MST) was 29.5 months. For both the 5-year survival rate and MST, there was significant difference between the lymph node negative (N0) and lymph node positive (N1/N2) patients (N-: 30.7%, N+: 0%, p=0.017, MST: N-: 38.3 months, N+: 10.5 months, p=0.014), according to the stage (III/B: 30%, IV: 11.1%, p=0.025, III/B: 40.1 months, IV: 17.8 months, p=0.04) and the number of metastases (1 metastasis: 26.6%, more than 1 metastasis: 0%, p=0.036, 1 metastasis: 35.2 months, more than 1 metastasis: 8.5 months, p=0.045). No significant difference was detected on the basis of histological type, pleural, vascular and lymphatic invasion. In patients where 1 metastasis was found within one lobe and there were no lymph node metastases, the 5-year survival rate was 42.8% and MST was 49 months. The complication rate was 28.5% and the 30-day mortality was 4.7% (1 patient). Reoperation was performed in 1 case, for thoracic wall haematoma. CONCLUSION: Primary lung tumours giving intrapulmonary metastases, under certain conditions (lymph node negativity, 1 metastasis in the same lobe), can be operated on with good survival possibilities.

AB - OBJECTIVE: The aim of this retrospective study was to establish the prognosis in lung tumour cases in which resection was followed by synchronous or metachronous intrapulmonary metastasis. METHODS: Between 1990 and 1999, 857 patients were operated on for primary lung cancer. Intrapulmonary metastases were observed in 21 patients. 11 cases were in stage III/B (on the basis of T4), and 10 were in stage IV (on the basis of M1). The histologic distribution of the primary tumours was 7 squamous cell carcinomas, 11 adenocarcinomas, 2 large cell carcinomas and 1 carcinoid. In 8 patients, histology demonstrated N1 or N2 lymph node metastasis. In 4 cases, there were more than one metastases. RESULTS: The 5-year survival was 21%, and the mean survival time (MST) was 29.5 months. For both the 5-year survival rate and MST, there was significant difference between the lymph node negative (N0) and lymph node positive (N1/N2) patients (N-: 30.7%, N+: 0%, p=0.017, MST: N-: 38.3 months, N+: 10.5 months, p=0.014), according to the stage (III/B: 30%, IV: 11.1%, p=0.025, III/B: 40.1 months, IV: 17.8 months, p=0.04) and the number of metastases (1 metastasis: 26.6%, more than 1 metastasis: 0%, p=0.036, 1 metastasis: 35.2 months, more than 1 metastasis: 8.5 months, p=0.045). No significant difference was detected on the basis of histological type, pleural, vascular and lymphatic invasion. In patients where 1 metastasis was found within one lobe and there were no lymph node metastases, the 5-year survival rate was 42.8% and MST was 49 months. The complication rate was 28.5% and the 30-day mortality was 4.7% (1 patient). Reoperation was performed in 1 case, for thoracic wall haematoma. CONCLUSION: Primary lung tumours giving intrapulmonary metastases, under certain conditions (lymph node negativity, 1 metastasis in the same lobe), can be operated on with good survival possibilities.

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