Pro-, antioxidant and rheologic studies in the blood of type 2 diabetic patients

B. Matkovics, Márta Kotormán, Ilona Sz Varga, Do Quy Hai, L. Salgó, Z. Novák

Research output: Article

14 Citations (Scopus)

Abstract

This study was conducted on type 2 non-insulin-dependent diabetes mellitus (NIDDM) cases and healthy blood donors. Lipid peroxidation (LP) products in plasma and red blood cell (RBC) hemolysates were estimated as total thiobarbituric acid reactive substances (TTBARS). The plasma and hemolysate reduced and oxidized glutathione (GSH and GSSG) levels are compared. In the hemolysates the antioxidant enzymes namely superoxide dismutase (SOD), glutathione peroxidase (GPx-ase), glutathione reductase (GR-ase) and catalase (C-ase) are also compared. The RBC filtration characteristics are determined and compared with controls: 1. LP and GSH in diabetic plasma were significantly higher, but in the hemolysate the GSH raised but the LP was significantly lower in diabetics than in healthy controls. 2. Superoxide dismutase and C-ase were significantly higher in NIDDM hemolysate. Contrary the GPx-ase activity was significantly lower in diabetics. 3. The diabetic RBCs filtration characteristics are changed in respects significantly namely the F1 was lower, the Tc and CR were higher. It means higher rigidity and oxidative damage of the membrane of diabetic RBCs.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalActa physiologica Hungarica
Volume85
Issue number2
Publication statusPublished - dec. 1 1997

ASJC Scopus subject areas

  • Physiology (medical)

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