Pro-, antioxidant and filtration changes in the blood of type 1 diabetic patients

B. Matkovics, Márta Kotormán, Ilona Sz Varga, Do Quy Hai, F. Román, Z. Novák

Research output: Article

6 Citations (Scopus)

Abstract

In our present work we attempt to clarify the pro-, antioxidant status (redox status) of blood and the red blood cell (RBC) filtration changes in type 1 (insulin dependent diabetes mellitus = IDDM) diabetic patients, broadening our biochemical knowledge about the mechanism of diasease, Further on we try to apply our observations in therapy. Our studies on enzymes and the pro- and antioxidant status in type 1 diabetes are closely related to earlier works. Our studies on antioxidants have been extended deeper on redox conditions for example on the reduced and oxidized glutalhione (GSH and GSSG) and glutathione reductase activity. The properties and changes of antioxidant enzyme activities (superoxide dismutase, glutathione peroxidase and catalase) as well as lipid peroxidation (LP) have been studied earlier without selecting the different type of human diabetics. At the same time the red blood cell filtration characteristics are compared also with normal values. The results of our studies confirmed the earlier findings that human diabetes is accompanied by a strong oxidative predominance (oxidative stress) in blood.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalActa physiologica Hungarica
Volume85
Issue number2
Publication statusPublished - dec. 1 1997

ASJC Scopus subject areas

  • Physiology (medical)

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