Prevention of apoptosis reperfusion renal injury by calcium channel blockers

Éva Toronyi, János Hamar, Ferenc Ferner, Béla Szende

Research output: Article

14 Citations (Scopus)

Abstract

Apoptosis has been shown in the literature to be the form of cell death occurring in renal tubular epithelial cells during the reperfusion phase after brief periods of renal ischemia. In the present study apoptosis was examined in the rat kidney in the first 24 hours after 30 min ischemia and apoptosis was influenced by administration of the Ca channel blockers Verapamil, Bepridil, Nifedipin and Sensit. Apoptosis was observed in the renal tubular cells two hours after the start of reperfusion and reached in maximum at hour 6. All above mentioned Ca channel blockers decreased the occurrence and degree of apoptosis.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalExperimental and Toxicologic Pathology
Volume51
Issue number3
DOIs
Publication statusPublished - máj. 1999

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology

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