Presence of the di-leucine motif in the cytoplasmic tail of the pig FcRn α chain

Yaofeng Zhao, I. Kacskovics, Zhihui Zhao, Lennart Hammarström

Research output: Article

8 Citations (Scopus)

Abstract

The sequence of the pig FcRn α chain was recently published. The lack of a conserved di-leucine motif in the cytoplasmic tail suggests a rare polymorphism in the described animal, alternatively, a sequencing error. We therefore cloned and sequenced the pig FcRn α chain. Our sequence, along with a previous NCBI GenBank submission and five pig derived EST clones clearly demonstrate the presence of di-leucine motif in the cytoplasmic tail of the pig FcRn. No polymorphism in the cytoplasmic tail-encoding region was found in 25 animals from six pig breeds based on single-stranded conformation polymorphism and sequencing analysis, suggesting that the previously described pig FcRn α chain may represent a sequencing error in the 3′ portion of the gene.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalVeterinary Immunology and Immunopathology
Volume96
Issue number3-4
DOIs
Publication statusPublished - dec. 15 2003

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Leucine
leucine
Tail
tail
Swine
swine
genetic polymorphism
swine breeds
single-stranded conformational polymorphism
Expressed Sequence Tags
Nucleic Acid Databases
animals
clones
Clone Cells
genes
Genes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology
  • veterinary(all)

Cite this

Presence of the di-leucine motif in the cytoplasmic tail of the pig FcRn α chain. / Zhao, Yaofeng; Kacskovics, I.; Zhao, Zhihui; Hammarström, Lennart.

In: Veterinary Immunology and Immunopathology, Vol. 96, No. 3-4, 15.12.2003, p. 229-233.

Research output: Article

Zhao, Yaofeng ; Kacskovics, I. ; Zhao, Zhihui ; Hammarström, Lennart. / Presence of the di-leucine motif in the cytoplasmic tail of the pig FcRn α chain. In: Veterinary Immunology and Immunopathology. 2003 ; Vol. 96, No. 3-4. pp. 229-233.
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