Preparation and structure of pyrazolo[3,4-d]pyrimidinones

Ferenc Miklós, Iván Kanizsai, Pál Sohár, Géza Stájer

Research output: Article

7 Citations (Scopus)


By means of the reactions of 5-amino-1-phenyl-4-pyrazolecarbohydrazide 1 with aroylalkane- and (bi)cycloalkanecarboxylic acids, the tri-, tetra- and pentacyclic pyrazolo[3,4-d]pyrimidines 2-6 were prepared. The acetylhydrazide 1a reacted with levulinic acid to yield a pyrazoloazepinone 7, together with the pyrrolopyrazolopyrimidinone 8, by acylation of the primary amine following intramolecular cyclization involving either the pyrazole carbon or the hydrazide imino group. After separation, the structures of the new compounds were established by means of NMR measurements.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalJournal of Molecular Structure
Issue number1-3
Publication statusPublished - jún. 3 2002


ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Inorganic Chemistry

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