Potential Role of Patients' CYP3A-Status in Clozapine Pharmacokinetics

Katalin Tóth, Gábor Csukly, Dávid Sirok, Ales Belic, Ádám Kiss, Edit Háfra, Máté Déri, Ádám Menus, I. Bitter, K. Monostory

Research output: Article

13 Citations (Scopus)

Abstract

Background: The atypical antipsychotic clozapine is effective in treatment-resistant schizophrenia; however, the success or failure of clozapine therapy is substantially affected by the variables that impact the clozapine blood concentration. Thus, elucidating the inter-individual differences in clozapine pharmacokinetics can facilitate the personalized therapy. Methods: Since a potential role in clozapine metabolism is assigned to CYP1A2, CYP2C19, CYP2D6 and CYP3A enzymes, the association between the patients' CYP status (CYP genotypes, CYP expression) and clozapine clearance was evaluated in 92 psychiatric patients. Results: The patients' CYP2C19 or CYP2D6 genotypes and CYP1A2 expression seemed to have no effect on clozapine serum concentration, whereas CYP3A4 expression significantly influenced the normalized clozapine concentration (185.53 ± 56.53 in low expressers vs 78.05 ± 29.57 or 66.52 ± 0.25 (ng/mL)/(mg/kg) in normal or high expressers, P < .0001), in particular that the patients expressed CYP1A2 at a relatively low level. The functional CYP3A51 allele seemed to influence clozapine concentrations in those patients who expressed CYP3A4 at low levels. The dose requirement for the therapeutic concentration of clozapine was substantially lower in low CYP3A4 expresser patients than in normal/high expressers (2.18 ± 0.64 vs 4.98 ± 1.40 mg/kg, P < .0001). Furthermore, significantly higher plasma concentration ratios of norclozapine/ clozapine and clozapine N-oxide/clozapine were observed in the patients displaying normal/high CYP3A4 expression than in the low expressers. Conclusion: Prospective assaying of CYP3A-status (CYP3A4 expression, CYP3A5 genotype) may better identify the patients with higher risk of inefficiency or adverse reactions and may facilitate the improvement of personalized clozapine therapy; however, further clinical studies are required to prove the benefit of CYP3A testing for patients under clozapine therapy.

Original languageEnglish
Pages (from-to)529-537
Number of pages9
JournalInternational Journal of Neuropsychopharmacology
Volume20
Issue number7
DOIs
Publication statusPublished - júl. 1 2017

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Potential Role of Patients' CYP3A-Status in Clozapine Pharmacokinetics'. Together they form a unique fingerprint.

  • Cite this