Post-source decay matrix-assisted laser desorption/ionization mass spectrometric study of tetracyclic 2,3-dihydro-1,5-benzothiazepines

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1 Citation (Scopus)

Abstract

The fragmentation behavior of six tetracyclic 2,3-dihydro-1,5- benzothiazepine derivatives cationized with protons and silver ions under post-source decay (PSD) matrix-assisted laser desorption/ionization (MALDI) conditions is reported. The protonated adduct ions decompose into several structurally important fragment ions, including substituted cyclopropane and benzohydrothiazole cations. Elimination of Ag and H and/or AgH from the silver-cationized adduct ions of these ([M+Ag]+) compounds was observed. It was also found that [M+Ag]+ produced silver-depleted fragment ions exclusively. Based on the PSD results a fragmentation pathway is proposed for the [M+H]+ and [M+Ag]+ precursor ions.

Original languageEnglish
Pages (from-to)1259-1264
Number of pages6
JournalRapid Communications in Mass Spectrometry
Volume18
Issue number12
DOIs
Publication statusPublished - júl. 12 2004

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry

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