Possible pathogenic nature of the recently discovered TT virus: Does it play a role in autoimmune rheumatic diseases?

Peter Gergely, Andras Perl, G. Poór

Research output: Article

47 Citations (Scopus)

Abstract

Pathogenesis of viral origin has long been suggested in autoimmune rheumatic diseases. Beside the well-defined virus induced transient or chronic rheumatic diseases often resembling systemic autoimmune disorders such as rheumatoid arthritis, viruses can contribute to disease pathogenesis by several different pathomechanisms. TT virus is a recently discovered virus of extremely high genetic diversity which commonly infects humans. Despite accumulated evidence on the biological characteristics of TTV, its pathogenicity is still in question; many consider TTV as a harmless endosymbiont. The recent paper overviews the biology of TT virus and investigates the hypothesis that TTV might have a causative role in human diseases with special attention to the possibility that TTV might trigger autoimmunity in rheumatic disorders.

Original languageEnglish
Pages (from-to)5-9
Number of pages5
JournalAutoimmunity Reviews
Volume6
Issue number1
DOIs
Publication statusPublished - nov. 2006

Fingerprint

Torque teno virus
Rheumatic Diseases
Autoimmune Diseases
Viruses
Autoimmunity
Virulence
Rheumatoid Arthritis
Chronic Disease

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

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abstract = "Pathogenesis of viral origin has long been suggested in autoimmune rheumatic diseases. Beside the well-defined virus induced transient or chronic rheumatic diseases often resembling systemic autoimmune disorders such as rheumatoid arthritis, viruses can contribute to disease pathogenesis by several different pathomechanisms. TT virus is a recently discovered virus of extremely high genetic diversity which commonly infects humans. Despite accumulated evidence on the biological characteristics of TTV, its pathogenicity is still in question; many consider TTV as a harmless endosymbiont. The recent paper overviews the biology of TT virus and investigates the hypothesis that TTV might have a causative role in human diseases with special attention to the possibility that TTV might trigger autoimmunity in rheumatic disorders.",
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