Possible involvement of capsaicin-sensitive sensory nerves in the regulation of intestinal blood flow in the dog

Zsuzsa Rózsa, G. Jancsó, V. Varró

Research output: Article

34 Citations (Scopus)

Abstract

1. The effect of capsaicin injected into the superior mesenteric artery has been studied on the intestinal blood flow in dogs. 2. Capsaicin evoked a marked dose-dependent increase in mesenterial blood flow in the dose range of 0.1-7 μg/kg. The intestinal vasodilatatory effect of capsaicin could invariably be demonstrated after pretreatment with adrenoceptor and dopamine receptor antagonists, as well as with the ganglion blocking agent hexamethonium. 3. Pretreatment with atropine significantly reduced, but did not abolish the increase in intestinal blood flow elicited by capsaicin. 4. Concomitant administration of somatostatin significantly inhibited both the atropine-sensitive and the atropineresistant components of the effect of capsaicin injected into the superior mesenteric artery. 5. Our results indirectly support the assumption that the intestinal vasodilatatory effect of capsaicin may be mediated by substance P release from capsaicin-sensitive paravascular nerve fibres associated with the blood vessels of the gastrointestinal tract. It is suggested that sensory substance P-containing nerve fibres may be involved in the regulation of the vascular reactions of the gut.

Original languageEnglish
Pages (from-to)352-356
Number of pages5
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume326
Issue number4
DOIs
Publication statusPublished - dec. 1984

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Capsaicin
Dogs
Superior Mesenteric Artery
Substance P
Atropine
Nerve Fibers
Blood Vessels
Hexamethonium
Dopamine Antagonists
Somatostatin
Ganglia
Adrenergic Receptors
Gastrointestinal Tract

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "Possible involvement of capsaicin-sensitive sensory nerves in the regulation of intestinal blood flow in the dog",
abstract = "1. The effect of capsaicin injected into the superior mesenteric artery has been studied on the intestinal blood flow in dogs. 2. Capsaicin evoked a marked dose-dependent increase in mesenterial blood flow in the dose range of 0.1-7 μg/kg. The intestinal vasodilatatory effect of capsaicin could invariably be demonstrated after pretreatment with adrenoceptor and dopamine receptor antagonists, as well as with the ganglion blocking agent hexamethonium. 3. Pretreatment with atropine significantly reduced, but did not abolish the increase in intestinal blood flow elicited by capsaicin. 4. Concomitant administration of somatostatin significantly inhibited both the atropine-sensitive and the atropineresistant components of the effect of capsaicin injected into the superior mesenteric artery. 5. Our results indirectly support the assumption that the intestinal vasodilatatory effect of capsaicin may be mediated by substance P release from capsaicin-sensitive paravascular nerve fibres associated with the blood vessels of the gastrointestinal tract. It is suggested that sensory substance P-containing nerve fibres may be involved in the regulation of the vascular reactions of the gut.",
keywords = "Atropine-resistant vasodilatation, Capsaicin-sensitive afferent nerves, Intestinal blood flow, Somatostatin, Substance P",
author = "Zsuzsa R{\'o}zsa and G. Jancs{\'o} and V. Varr{\'o}",
year = "1984",
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T1 - Possible involvement of capsaicin-sensitive sensory nerves in the regulation of intestinal blood flow in the dog

AU - Rózsa, Zsuzsa

AU - Jancsó, G.

AU - Varró, V.

PY - 1984/12

Y1 - 1984/12

N2 - 1. The effect of capsaicin injected into the superior mesenteric artery has been studied on the intestinal blood flow in dogs. 2. Capsaicin evoked a marked dose-dependent increase in mesenterial blood flow in the dose range of 0.1-7 μg/kg. The intestinal vasodilatatory effect of capsaicin could invariably be demonstrated after pretreatment with adrenoceptor and dopamine receptor antagonists, as well as with the ganglion blocking agent hexamethonium. 3. Pretreatment with atropine significantly reduced, but did not abolish the increase in intestinal blood flow elicited by capsaicin. 4. Concomitant administration of somatostatin significantly inhibited both the atropine-sensitive and the atropineresistant components of the effect of capsaicin injected into the superior mesenteric artery. 5. Our results indirectly support the assumption that the intestinal vasodilatatory effect of capsaicin may be mediated by substance P release from capsaicin-sensitive paravascular nerve fibres associated with the blood vessels of the gastrointestinal tract. It is suggested that sensory substance P-containing nerve fibres may be involved in the regulation of the vascular reactions of the gut.

AB - 1. The effect of capsaicin injected into the superior mesenteric artery has been studied on the intestinal blood flow in dogs. 2. Capsaicin evoked a marked dose-dependent increase in mesenterial blood flow in the dose range of 0.1-7 μg/kg. The intestinal vasodilatatory effect of capsaicin could invariably be demonstrated after pretreatment with adrenoceptor and dopamine receptor antagonists, as well as with the ganglion blocking agent hexamethonium. 3. Pretreatment with atropine significantly reduced, but did not abolish the increase in intestinal blood flow elicited by capsaicin. 4. Concomitant administration of somatostatin significantly inhibited both the atropine-sensitive and the atropineresistant components of the effect of capsaicin injected into the superior mesenteric artery. 5. Our results indirectly support the assumption that the intestinal vasodilatatory effect of capsaicin may be mediated by substance P release from capsaicin-sensitive paravascular nerve fibres associated with the blood vessels of the gastrointestinal tract. It is suggested that sensory substance P-containing nerve fibres may be involved in the regulation of the vascular reactions of the gut.

KW - Atropine-resistant vasodilatation

KW - Capsaicin-sensitive afferent nerves

KW - Intestinal blood flow

KW - Somatostatin

KW - Substance P

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