Possible biological and clinical applications of phenothiazines

Borisz Varga, Ákos Csonka, Andrea Csonka, J. Molnár, Leonard Amaral, G. Spengler

Research output: Review article

17 Citations (Scopus)

Abstract

Phenothiazines have been used in many areas of medicine, mainly in psychopharmacology. These compounds are able to effectively inhibit dopamine, histamine, serotonin, acetylcholine, and α-adrenergic receptors; thus, their effect and side-effect profiles are extremely diverse. Besides their antipsychotic activity, phenothiazines have a significant antimicrobial effect as well, since they can enhance the bactericidal function of macrophages and inhibit efflux pumps. They are also able to eliminate bacterial resistance plasmids and destroy bacteria by their membrane-destabilizing effect. Their antiviral, antiprotozoal, antifungal, and antiprion activities have also been described. Phenothiazines have also been proven to destroy cancer cells and sensitize them to chemotherapy. Anti-angiogenesis and anticancer stem cell activities have also been reported, and they might be applied as adjuvants in the treatment of infections and tumors in the future. Finally, phenothiazines can also be effective in the treatment of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Original languageEnglish
Pages (from-to)5983-5993
Number of pages11
JournalAnticancer Research
Volume37
Issue number11
DOIs
Publication statusPublished - nov. 1 2017

Fingerprint

Phenothiazines
Psychopharmacology
Cholinergic Receptors
Neurodegenerative Diseases
Adrenergic Receptors
Histamine
Antipsychotic Agents
Antiviral Agents
Parkinson Disease
Dopamine
Neoplasms
Serotonin
Alzheimer Disease
Plasmids
Stem Cells
Macrophages
Medicine
Bacteria
Drug Therapy
Membranes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Possible biological and clinical applications of phenothiazines. / Varga, Borisz; Csonka, Ákos; Csonka, Andrea; Molnár, J.; Amaral, Leonard; Spengler, G.

In: Anticancer Research, Vol. 37, No. 11, 01.11.2017, p. 5983-5993.

Research output: Review article

Varga, Borisz ; Csonka, Ákos ; Csonka, Andrea ; Molnár, J. ; Amaral, Leonard ; Spengler, G. / Possible biological and clinical applications of phenothiazines. In: Anticancer Research. 2017 ; Vol. 37, No. 11. pp. 5983-5993.
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