Polymorphism of the tumour necrosis factor-alpha and lymphotoxin-alpha genes in hairy cell leukaemia

Judith Demeter, Franz Porzsolt, Stephanie Rämisch, Mathias Schmid, Gerald Messer

Research output: Article

15 Citations (Scopus)

Abstract

Hairy cell leukaemia (HCL) is a rare chronic B lymphoproliferative disorder which can lead to severe pancytopenia and several immunologic abnormalities. The pathogenetic role of tumour necrosis factor (TNF)-α in HCL prompted us to study the potential contribution of functionally important genetic polymorphisms of the TNF gene cluster in a large group of patients with HCL. The TNF-α (-308 bp) promoter/enhancer point mutation and two polymorphisms located within the first intron of the lymphotoxin (LT)-α gene showed neither significant allelic deviation for the patient group nor, after analysis of clinical characteristics such as blood counts, stable or progressive disease or response to therapy.

Original languageEnglish
Pages (from-to)132-134
Number of pages3
JournalBritish Journal of Haematology
Volume97
Issue number1
DOIs
Publication statusPublished - jan. 1 1997

ASJC Scopus subject areas

  • Hematology

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