Poly(amino acid)s: Promising enzymatically degradable stealth coatings for liposomes

Birgit Romberg, Josbert M. Metselaar, Lajos Baranyi, Cor J. Snel, Rolf Bünger, Wim E. Hennink, Janos Szebeni, Gert Storm

Research output: Article

60 Citations (Scopus)

Abstract

Poly(amino acid)s (PAAs) were evaluated as coating polymers for long-circulating liposomes. The pharmacokinetics of PAA-coated liposomes were assessed in rats. Prolonged circulation times were obtained, comparable to those reported for poly(ethylene glycol) (PEG)-liposomes. Besides, the enzymatic degradability of PAAs was studied. PAAs - in free as well as liposome-associated form - are degradable by proteases, which is beneficial for reducing the risks of accumulation in vivo. Furthermore, complement activation by PAA-liposomes was evaluated in vitro and in vivo. Like other liposome types, they appear to activate the complement system. However, a role of endotoxin contamination of the PAA-liposome formulations used cannot be excluded in our complement activation studies.

Original languageEnglish
Pages (from-to)186-189
Number of pages4
JournalInternational Journal of Pharmaceutics
Volume331
Issue number2
DOIs
Publication statusPublished - márc. 1 2007

ASJC Scopus subject areas

  • Pharmaceutical Science

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    Romberg, B., Metselaar, J. M., Baranyi, L., Snel, C. J., Bünger, R., Hennink, W. E., Szebeni, J., & Storm, G. (2007). Poly(amino acid)s: Promising enzymatically degradable stealth coatings for liposomes. International Journal of Pharmaceutics, 331(2), 186-189. https://doi.org/10.1016/j.ijpharm.2006.11.018