Plerixafor to rescue failing chemotherapy-based stem cell mobilization: It's not too late

Grzegorz W. Basak, Gabor Mikala, Zdenek Koristek, Ozren Jaksic, Sandra Basic-Kinda, Andrea Cegledi, Marienn Reti, Tamas Masszi, Jiri Mayer, Sebastian Giebel, Kai Hbel, Boris Labar, Wieslaw Wiktor-Jedrzejczak

Research output: Article

21 Citations (Scopus)

Abstract

Plerixafor can rescue the outcome of failing chemotherapy-based stem cell mobilization. However, the optimal time for plerixafor injection in this setting has not been determined. This was investigated by retrospective analysis of data from 48 mobilizations with plerixafor, chemotherapy, and granulocyte-colony stimulating factor (G-CSF). The required yield of 2.0×10 6 CD34+ cells/kg was collected from 71% of patients; the median total yield was 4.1 × 10 6 CD34+ cells/kg. Patients to whom plerixafor was administered late (≥15 days) after chemotherapy, after a long duration (≥13 days) of treatment with G-CSF, or when the white blood cell count was high (≥20 × 10 9/L) were mobilized as efficiently as other patients. Plerixafor was shown to rescue mobilizations at a comparable rate in patients with critically low levels of peripheral blood CD34+ cells (<3/L) and those with higher concentrations. These data suggest that late administration of plerixafor in the course of chemotherapy-based mobilization does not contribute to the failure of this strategy.

Original languageEnglish
Pages (from-to)1711-1719
Number of pages9
JournalLeukemia and Lymphoma
Volume52
Issue number9
DOIs
Publication statusPublished - szept. 2011

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Basak, G. W., Mikala, G., Koristek, Z., Jaksic, O., Basic-Kinda, S., Cegledi, A., Reti, M., Masszi, T., Mayer, J., Giebel, S., Hbel, K., Labar, B., & Wiktor-Jedrzejczak, W. (2011). Plerixafor to rescue failing chemotherapy-based stem cell mobilization: It's not too late. Leukemia and Lymphoma, 52(9), 1711-1719. https://doi.org/10.3109/10428194.2011.578312