Myeloma multiplex kórlefolyása során megjeleno plazmasejtes borinfiltráció

Katalin Molnár, I. Karádi, István Sugár, Z. Sápi, Márta Marschalkó, Éva Pálinger, Z. Darvas, Péter Pócza, A. Falus, András Vereczkei, J. Várkonyi

Research output: Article

Abstract

Authors present a case of a therapy-resistant multiple mycloma who developed plasmacytic skin infiltration in the course of the disease. Aim: To define characteristics of skin infiltrating plasma cells, which differentiate them from those cells residing in the bone marrow in order to contribute to a better understanding of the epidermoinvasion process. Methods: Histidine decarboxylase is the only enzyme capable for histamine synthesis having significance in cell proliferation. Histidine decarboxylase was determined in skin samples and bone marrow slides by immunohistochemical procedures and in bone marrow cells using flow cytometry analysis. Results: The histidine decarboxylase expression of plasma cells participating in skin invasion desappeared, while that of bone marrow plasma cells remained. Conclusions: Authors conclude that the histidine decarboxylase loss would serve as an evidence for the dedifferentation of epidermoinvasive cells as being the result of fundamental changes in histamin metabolism. As extramedullary myeloma cells differ from those residing in the bone marrow, their therapeutical response might also be different.

Original languageHungarian
Pages (from-to)877-881
Number of pages5
JournalOrvosi Hetilap
Volume149
Issue number19
DOIs
Publication statusPublished - máj. 11 2008

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Histidine Decarboxylase
Multiple Myeloma
Plasma Cells
Skin
Bone Marrow
Bone Marrow Cells
Histamine
Flow Cytometry
Cell Proliferation
Enzymes

Keywords

  • Histidine decarboxylase
  • Multiple myeloma
  • Skin infiltration

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Myeloma multiplex kórlefolyása során megjeleno plazmasejtes borinfiltráció. / Molnár, Katalin; Karádi, I.; Sugár, István; Sápi, Z.; Marschalkó, Márta; Pálinger, Éva; Darvas, Z.; Pócza, Péter; Falus, A.; Vereczkei, András; Várkonyi, J.

In: Orvosi Hetilap, Vol. 149, No. 19, 11.05.2008, p. 877-881.

Research output: Article

Molnár, Katalin ; Karádi, I. ; Sugár, István ; Sápi, Z. ; Marschalkó, Márta ; Pálinger, Éva ; Darvas, Z. ; Pócza, Péter ; Falus, A. ; Vereczkei, András ; Várkonyi, J. / Myeloma multiplex kórlefolyása során megjeleno plazmasejtes borinfiltráció. In: Orvosi Hetilap. 2008 ; Vol. 149, No. 19. pp. 877-881.
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abstract = "Authors present a case of a therapy-resistant multiple mycloma who developed plasmacytic skin infiltration in the course of the disease. Aim: To define characteristics of skin infiltrating plasma cells, which differentiate them from those cells residing in the bone marrow in order to contribute to a better understanding of the epidermoinvasion process. Methods: Histidine decarboxylase is the only enzyme capable for histamine synthesis having significance in cell proliferation. Histidine decarboxylase was determined in skin samples and bone marrow slides by immunohistochemical procedures and in bone marrow cells using flow cytometry analysis. Results: The histidine decarboxylase expression of plasma cells participating in skin invasion desappeared, while that of bone marrow plasma cells remained. Conclusions: Authors conclude that the histidine decarboxylase loss would serve as an evidence for the dedifferentation of epidermoinvasive cells as being the result of fundamental changes in histamin metabolism. As extramedullary myeloma cells differ from those residing in the bone marrow, their therapeutical response might also be different.",
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AU - Sápi, Z.

AU - Marschalkó, Márta

AU - Pálinger, Éva

AU - Darvas, Z.

AU - Pócza, Péter

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AU - Vereczkei, András

AU - Várkonyi, J.

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N2 - Authors present a case of a therapy-resistant multiple mycloma who developed plasmacytic skin infiltration in the course of the disease. Aim: To define characteristics of skin infiltrating plasma cells, which differentiate them from those cells residing in the bone marrow in order to contribute to a better understanding of the epidermoinvasion process. Methods: Histidine decarboxylase is the only enzyme capable for histamine synthesis having significance in cell proliferation. Histidine decarboxylase was determined in skin samples and bone marrow slides by immunohistochemical procedures and in bone marrow cells using flow cytometry analysis. Results: The histidine decarboxylase expression of plasma cells participating in skin invasion desappeared, while that of bone marrow plasma cells remained. Conclusions: Authors conclude that the histidine decarboxylase loss would serve as an evidence for the dedifferentation of epidermoinvasive cells as being the result of fundamental changes in histamin metabolism. As extramedullary myeloma cells differ from those residing in the bone marrow, their therapeutical response might also be different.

AB - Authors present a case of a therapy-resistant multiple mycloma who developed plasmacytic skin infiltration in the course of the disease. Aim: To define characteristics of skin infiltrating plasma cells, which differentiate them from those cells residing in the bone marrow in order to contribute to a better understanding of the epidermoinvasion process. Methods: Histidine decarboxylase is the only enzyme capable for histamine synthesis having significance in cell proliferation. Histidine decarboxylase was determined in skin samples and bone marrow slides by immunohistochemical procedures and in bone marrow cells using flow cytometry analysis. Results: The histidine decarboxylase expression of plasma cells participating in skin invasion desappeared, while that of bone marrow plasma cells remained. Conclusions: Authors conclude that the histidine decarboxylase loss would serve as an evidence for the dedifferentation of epidermoinvasive cells as being the result of fundamental changes in histamin metabolism. As extramedullary myeloma cells differ from those residing in the bone marrow, their therapeutical response might also be different.

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