Physicochemical characteristics of novel P-glycoprotein inhibitors of the cage dimeric 1,4-dihydropyridine type

J. Wollmann, J. Molnár, Andreas Hilgeroth

Research output: Article

2 Citations (Scopus)

Abstract

Physicochemical characteristics of two structurally different cage dimeric 1,4-dihydropyridines HX (1) and CC (2) have been determined and compared to their P-glycoprotein inhibiting properties. While the weakly basic compound (1) showed pH-dependent apparent partition coefficients (log D), the neutral compound (2) proved to have almost identical log D values at varying pH-values. The subsequent determination of partition coefficients (log P) resulted in comparably low log P values revealing a less lipophilic compound character. Determined significantly differing P-glycoprotein (P-gp) inhibitory properties indicated that the lipophilicity of the compounds does not play a decisive role for the P-gp activity.

Original languageEnglish
Pages (from-to)565-568
Number of pages4
JournalMedicinal Chemistry
Volume2
Issue number6
Publication statusPublished - nov. 2006

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P-Glycoprotein
1,4-dihydropyridine

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Physicochemical characteristics of novel P-glycoprotein inhibitors of the cage dimeric 1,4-dihydropyridine type. / Wollmann, J.; Molnár, J.; Hilgeroth, Andreas.

In: Medicinal Chemistry, Vol. 2, No. 6, 11.2006, p. 565-568.

Research output: Article

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