Phenotypic and genetic characterisation of methicillin-resistant Staphylococcus aureus strains isolated from the university hospitals of Debrecen

J. Szabó, Z. Dombrádi, O. Dobay, P. Orosi, J. Kónya, K. Nagy, F. Rozgonyi

Research output: Article

8 Citations (Scopus)

Abstract

The purpose of this study was to characterise methicillin-resistant Staphylococcus aureus (MRSA) strains isolated in 2005 at the university hospitals of Debrecen, Hungary. Three hundred and thirty-nine MRSA strains were isolated from 102 patients at 18 different clinics. Their sensitivity to oxacillin and ten other antibiotics was determined. For genotypic analysis, phage typing and pulsed-field gel electrophoresis (PFGE) was performed. The rate of MRSA strains increased to 7.2% in 2005, especially at the clinics of surgery, pulmonology and paediatrics. No vancomycin- or teicoplanin-resistant strains were found. The resistance to erythromycin, clindamycin and ciprofloxacin was nearly 100% and multi-resistance was very frequent. Fifty-eight percent of the isolates belonged to mixed phage types and 8% was non-typable. One PFGE clone contained 58.2% of all strains and two further major clones were found at a separately located clinical block, indicating intra-hospital spread. We can conclude that MRSA exhibits an increasing nosocomial problem also in Hungary.

Original languageEnglish
Pages (from-to)129-136
Number of pages8
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume28
Issue number2
DOIs
Publication statusPublished - febr. 1 2009

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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