Pharmacological analysis of α2-adrenoceptor subtypes mediating analgesic, anti-inflammatory and gastroprotective actions

K. Gyires, Z. S. Zádori, N. Shujaa, M. Al-Khrasani, B. Pap, M. M. Mózes, P. Mátyus

Research output: Article

10 Citations (Scopus)

Abstract

Our previous findings suggest that α2-adrenoceptor stimulants induce gastroprotective action, the effect is likely to be mediated by α2B-adrenoceptor subtype. Clonidine (0.094 μmol/kg p.o.) and rilmenidine (0.014 μmol/kg p.o.) in gastroprotective dose range, as well as ST-91 (2.2 μmol/kg p.o.), a clonidine analogue showing higher affinity to α2B-adrenoceptor subtype than to α2A-one, inhibited the carrageenan-induced hyperalgesia in Randall-Selitto test, the antinociceptive action was reversed by yohimbine (5 μmol/kg s.c.) and the α2B-adrenoceptor antagonist prazosin (0.24 μmol/kg i.p.). Similarly, clonidine and rilmenidine in the same dose range reduced the oedema formation induced by carrageenan, yohimbine and the α2A- adrenoceptor antagonist BRL-44408 (3 μmol/kg i.p.) inhibited the anti-inflammatory effect; however, prazosin failed to affect it. These results suggest that α2B/C-like adrenoceptor subtype may be involved in the antihyperalgesic action, but not in the antiphlogistic effect of α2-adrenoceptor stimulants. The later effect may be mediated by α2A-like adrenoceptor subtype.

Original languageEnglish
Pages (from-to)171-179
Number of pages9
JournalInflammoPharmacology
Volume17
Issue number3
DOIs
Publication statusPublished - júl. 1 2009

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ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Pharmacology (medical)

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