Pharmaco-biochemical studies on cytotoxic polyol derivatives-II. The effect of biological alkylating agents on the thermal-denaturation properties of DNA

A. Jeney, I. Szabó, T. Vályi-Nagy, L. Institoris, J. Szabó

Research output: Article

9 Citations (Scopus)

Abstract

The effect of the biological alkylating agents on the thermal-denaturation profile of DNA and on nucleohistone was investigated. It was established that while the mustard derivatives and dimethylmyleran profoundly, though differentially, altered the thermal-denaturation property of DNA, the dibromohexitols and mannitolmyleran proved to be ineffective. On the other hand the dibromohexitols and mannitolmyleran are capable to blocking the effect of histone on the Tm point of DNA.

Original languageEnglish
Pages (from-to)297-302
Number of pages6
JournalEuropean Journal of Cancer (1965)
Volume6
Issue number4
DOIs
Publication statusPublished - aug. 1970

ASJC Scopus subject areas

  • Medicine(all)

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