Permanent depression of plasma cGMP during long-term space flight

A. Rössler, V. Noskov, Z. László, V. V. Polyakow, H. G. Hinghofer-Szalkay

Research output: Article

11 Citations (Scopus)


The purpose of this study was to investigate plasma concentrations of cyclic guanosine monophosphate (cGMP) and atrial natriuretic peptide (ANP) during and after real and simulated space flight. Venous blood was obtained 3 min after the beginning and 2 min after the lower body negative pressure maneuver in two cosmonauts preflight (supine), inflight, and postflight (supine) and in five other subjects before, at the end, and 4 days after a 5-day head-down tilt (-6°) bed rest. In cosmonaut 1 (10 days in space), plasma cGMP fell from preflight 4.3 to 1.4 nM on flight day 6, and was 3.0 nM on the fourth day after landing. In cosmonaut 2 (438 days in space), it fell from preflight 4.9 to 0.5 nM on flight day 3, and stayed <0.1 nM with 5, 9, and 14 months in space, as well as on the fourth day after landing. Three months after the flight his plasma cGMP was back to normal (6.3 nM). Cosmonaut 2 also displayed relatively low inflight ANP values but returned to preflight level immediately after landing. In a ground-based simulation on five other persons, supine plasma cGMP was reduced by an average of 30 % within 5 days of 6° head-down tilt bed rest. The data consistently demonstrate lowered plasma cGMP with real and simulated weightlessness, and a complete disappearance of cGMP from plasma during, and shortly after long-duration space flight.

Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalPhysiological Research
Issue number1
Publication statusPublished - ápr. 3 2001

ASJC Scopus subject areas

  • Physiology

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  • Cite this

    Rössler, A., Noskov, V., László, Z., Polyakow, V. V., & Hinghofer-Szalkay, H. G. (2001). Permanent depression of plasma cGMP during long-term space flight. Physiological Research, 50(1), 83-90.