A paraneopláziás neurológiai szindrómák laboratóriumi diagnosztikája és immunológiai vonatkozásai

Zsófia Hayden, Katalin Böröcz, Zsuzsanna Csizmadia, Zoltán Kellermayer, P. Balogh, Tímea Berki

Research output: Article

Abstract

Paraneoplastic neurologic syndromes (PNS) and autoimmune encephalitis (AE) are rare neurological disorders, which have similar symptoms, but vary in outcome and treatment strategy. In our retrospective statistical study we evaluated the autoantibody test results of serum and CSF from 2362 patients with suspected PNS and 1034 patients with suspected AE. For autoantibody testing, immunoblot assay (PNS) and cell-based indirect immunofluorescence assay (AE) were used. Autoantibodies were present in 8% of patients with suspected PNS: anti-Yo > anti-Hu > anti-Ma2 > anti-CV2 > anti-titin > anti-Zic4 > anti-amphiphysin > anti-Ri > anti-GAD65 > anti-Sox1 > anti-recoverin. Mostly elderly women were affected. Autoantibodies were present in 5.8% of patients with suspected AE: anti-NMDAR (young women) > anti-LGI1 (middle-aged men) > anti-GABABR (elderly men) > anti-Caspr2 (adult men). Our results correspond to the data described in the literature. The number of patients with suspected PNS and AE shows an increasing tendency, where the autoantibody testing with modern laboratory diagnostic methods helps in the early introduction of the appropriate therapy.

Original languageHungarian
Pages (from-to)254-260
Number of pages7
JournalMagyar onkologia
Volume63
Issue number3
Publication statusPublished - szept. 18 2019

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hayden, Z., Böröcz, K., Csizmadia, Z., Kellermayer, Z., Balogh, P., & Berki, T. (2019). A paraneopláziás neurológiai szindrómák laboratóriumi diagnosztikája és immunológiai vonatkozásai. Magyar onkologia, 63(3), 254-260.