Oxidative stress changes in L-arginine-induced pancreatitis in rats

Research output: Article

28 Citations (Scopus)

Abstract

The important role of oxygen radicals in acute experimental pancreatitis was demonstrated by study of the changes in the antioxidant system in the blood, liver, kidney, and pancreas of rats after the administration of a large quantity of L-arginine (L-Arg). The changes in lipid peroxidation and in reduced and oxidized glutathione were followed, as well as the activities of peroxide-decomposing enzymes (glutathione peroxidase and catalase) and H2O2-producing superoxide dismutases. The results demonstrated that 'oxidative stress' develops and acute pancreatitis appears rapidly after L- Arg treatment. Oxidative stress symptoms are expressed 24 h after the final treatment. Slow restitution of the studied antioxidant system can be demonstrated as early as after 48 h.

Original languageEnglish
Pages (from-to)355-359
Number of pages5
JournalPancreas
Volume14
Issue number4
DOIs
Publication statusPublished - máj. 1997

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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