Oxazepines and thiazepines, XXIV synthesis of optically active 2,3-dihydro-2-methyl-1,5-benzoxazepin-4(5 H)-ones

A. Lévai, Jürgen Ott, Günther Snatzke

Research output: Article

14 Citations (Scopus)

Abstract

2,3-Dihydro-2(R)-methyl-1,5-benzoxazepin-4(5 H)-one [(R)-3] and its enantiomer (S)-3 have been synthesized via the optical resolution and subsequent chemical transformations of (±)-3-(2-nitrophenoxy)butyric acid (1). Compounds (R)-3 and (S)-3 were converted into optically active 1,5-benzoxazepines (R)-7-(R)-14 and (S)-15-(S)-32.

Original languageEnglish
Pages (from-to)919-930
Number of pages12
JournalMonatshefte fur Chemie
Volume123
Issue number10
DOIs
Publication statusPublished - okt. 1992

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Thiazepines
Oxazepines
Butyric Acid
Enantiomers

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Oxazepines and thiazepines, XXIV synthesis of optically active 2,3-dihydro-2-methyl-1,5-benzoxazepin-4(5 H)-ones. / Lévai, A.; Ott, Jürgen; Snatzke, Günther.

In: Monatshefte fur Chemie, Vol. 123, No. 10, 10.1992, p. 919-930.

Research output: Article

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abstract = "2,3-Dihydro-2(R)-methyl-1,5-benzoxazepin-4(5 H)-one [(R)-3] and its enantiomer (S)-3 have been synthesized via the optical resolution and subsequent chemical transformations of (±)-3-(2-nitrophenoxy)butyric acid (1). Compounds (R)-3 and (S)-3 were converted into optically active 1,5-benzoxazepines (R)-7-(R)-14 and (S)-15-(S)-32.",
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AU - Snatzke, Günther

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KW - Determination of absolute configuration

KW - Determination of optical purity

KW - Optical resolution

KW - Ring closure of aminocarboxylic acids

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