Oxamides as novel NR2B selective NMDA receptor antagonists

Gizella Barta-Szalai, István Borza, Éva Bozó, Csilla Kiss, B. Ágai, Ágnes Proszenyák, György M. Keseru, Anikó Gere, Sándor Kolok, Kornél Galgóczy, Csilla Horváth, Sándor Farkas, György Domány

Research output: Article

36 Citations (Scopus)

Abstract

A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test.

Original languageEnglish
Pages (from-to)3953-3956
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number15
DOIs
Publication statusPublished - aug. 2 2004

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Pain Measurement
N-Methyl-D-Aspartate Receptors
Formaldehyde
Analgesics
indole
oxamide
NR2B NMDA receptor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Barta-Szalai, G., Borza, I., Bozó, É., Kiss, C., Ágai, B., Proszenyák, Á., ... Domány, G. (2004). Oxamides as novel NR2B selective NMDA receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 14(15), 3953-3956. https://doi.org/10.1016/j.bmcl.2004.05.053

Oxamides as novel NR2B selective NMDA receptor antagonists. / Barta-Szalai, Gizella; Borza, István; Bozó, Éva; Kiss, Csilla; Ágai, B.; Proszenyák, Ágnes; Keseru, György M.; Gere, Anikó; Kolok, Sándor; Galgóczy, Kornél; Horváth, Csilla; Farkas, Sándor; Domány, György.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 15, 02.08.2004, p. 3953-3956.

Research output: Article

Barta-Szalai, G, Borza, I, Bozó, É, Kiss, C, Ágai, B, Proszenyák, Á, Keseru, GM, Gere, A, Kolok, S, Galgóczy, K, Horváth, C, Farkas, S & Domány, G 2004, 'Oxamides as novel NR2B selective NMDA receptor antagonists', Bioorganic and Medicinal Chemistry Letters, vol. 14, no. 15, pp. 3953-3956. https://doi.org/10.1016/j.bmcl.2004.05.053
Barta-Szalai, Gizella ; Borza, István ; Bozó, Éva ; Kiss, Csilla ; Ágai, B. ; Proszenyák, Ágnes ; Keseru, György M. ; Gere, Anikó ; Kolok, Sándor ; Galgóczy, Kornél ; Horváth, Csilla ; Farkas, Sándor ; Domány, György. / Oxamides as novel NR2B selective NMDA receptor antagonists. In: Bioorganic and Medicinal Chemistry Letters. 2004 ; Vol. 14, No. 15. pp. 3953-3956.
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